신 공여자 에서 신장 깊이 측정에 따른 사구체여과율의 비교에 관한 고찰

• 영문명: Study on Glomerular Filtration Rate comparison according to renal depth measurement of kidney donors
• 발행기관: 대한핵의학기술학회
• 저자명: 이한울(Han Wool Lee) 박민수(Min Soo Park) 강천구(Chun Goo Kang) 조석원(Seok Won Cho) 김주연(Joo Yeon Kim) 권오준(O Jun Kwon) 임한상(Han Sang Lim) 김재삼(Jae Sam Kim) 박훈희(Hoon-Hee Park)
• 간행물 정보: 『핵의학기술』Vol.18 No.2, 48~56쪽, 전체 9쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2014.11.30

영문 초록

Purpose ⁹⁹ᵐTc-DTPA renal scintigraphy serves as a key indicator to measure a kidney donor's Glomerular Filtration Rate (GFR) and determine the possibility of kidney transplant. The Gates method utilized to measure GFR considers 3 variables of renal depth, injection dose, and net kidney counts. In this research, we seek to compare changes in kidney donors' GFR according to renal depth measurement methods of the 3 variables. Materials and Methods We investigated 32 kidney donors who had visited the hospital from October, 2013 to March, 2014 and received abdominal CT and ⁹⁹ᵐTc-DTPA GFR examination. With the cross-section image of the CT and the lateral image from a gamma camera, we measured the renal depth and compared with renal depth calculation equations- Tonnesen, Taylor, and Itoh methods. Renal depth-specific GFR was calculated by using Xeleris Ver. 2.1220 of GE. Then the results were compared with MDRD (Modification of Diet Renal Disease) GFRs based on serum creatinine level. Results The renal depths measured based on the CT and gamma camera images showed high correlation. Tonessen equation gave the lowest GFR value while the value calculated by using the renal depth of CT image was the highest with a 16.62% gap. MDRD GFR showed no statistically significant difference among values calculated through Taylor, Itoh, CT and gamma camera renal depth application (P>0.05), but exhibited a statistically significant change in the value based on Tonnesen equation (P<0.05). Conclusion This research has found that, in GFR evaluation in kidney donors by utilizing ⁹⁹ᵐTc-DTPA, Tonnesen equation-based Gates method underestimated the value than the MDRD GFR. Therefore, if a MDRD GFR value shows a huge difference from the actual examination value, using an image-based renal depth measurement, instead of Tonnesen equation applied to Gates method, is expected to give an accurate GFR value to kidney donors.

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대상 및 방법

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결론 및 고찰

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REFERENCES

키워드

Renal Depth GFR Gates Method MDRD