Article 고정상 추출법을 이용한 효율적인 [¹¹C]methionine의 합성

• 영문명: Simple and Highly Efficient Synthesis of [¹¹C]methionine Using Solid-Phase Extraction Method
• 발행기관: 대한핵의학기술학회
• 저자명: 임성재(Sung-Jae Lim) 문우연(Woo-Yeon Moon) 최재칠(Jae-Chil Choi) 조시만(Shee-Man Cho) 오승준(Seung-Jun Oh)
• 간행물 정보: 『핵의학기술』Vol.12 No.2, 181~183쪽, 전체 3쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2008.10.30

영문 초록

We developed simple and highly efficient synthesis method for [¹¹C]methionine using solid-phase extraction method. For synthesis, we used C18 cartridge. [¹¹C]methionine was synthesized on C18 cartridge according to the solid-phase [¹¹C]methylation of precursor L-homocysteine thiolactone hydrochloride. The radiochemical yields of [¹¹C]methionine was 48.9±7.93% decay corrected (results of 30 syntheses, mean±SD), with average production higher than 180 mCi. This procedure showed high yield and simple synthesis of [¹¹C]methionine.

목차

INTRODUCTION

METHODS

RESULTS

CONCLUSION

REFERENCES

키워드

[¹¹C]methionine Solid phase cartridge