국내 감초 신품종의 급성 췌장염 보호 효과

• 영문명: Protective Effect of Glycyrrhiza New Domestic Variety on the Acute Pancreatitis
• 발행기관: 한국자원식물학회
• 저자명: 김동구 민경현
• 간행물 정보: 『한국자원식물학회지』제36권 제4호, 282~289쪽, 전체 8쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2023.08.31

영문 초록

Glycyrrhiza korshinskyi Grig. (Gk), which is a new variety of Glycyrrhiza, was developed by the National Institute of Horticultural and Herbal Science in Korea Rural Development Administration. It is improved the limitations of traditional Glycrrhiza species such as G. uralensis Fisch., G. glabra L., and G. inflata Batal. and has been reported various pharmacological effects. The aim of this study is to investigate the protective effect of Gk on the acute pancreatitis, because which has not been revealed yet. AP was induced via intraperitoneal injection of cerulein (50 ㎍/㎏) hourly for 7 times in C57BL/6 mice. Gk water extract (20 or 50 ㎎/㎏) or saline was administrated via oral gavage 1 h before the first injection of cerulein. The mice were sacrificed at 5 h after the final injection of cerulein. The inflammatory cell infiltration in pancreatic tissue was decreased by the administration of Gk water extract compared to the AP group. Also, serum amylase and lipase levels were decreased by the administration of Gk water extract compared to the AP group. These results suggest that Gk have protective effect on the acute pancreatitis.

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키워드

Acute pancreatitis Cerulein Glycyrrhiza Glycyrrhiza korshinskyi Grig