인가목(Rosa acicularis Lindl.) 잎 추출물의 대식세포에서 자가포식 유도활성

• 영문명: Induction of Autophagy by Rosa acicularis Leaves Extracts in RAW264.7 Cells
• 발행기관: 한국자원식물학회
• 저자명: 최정원 정진부
• 간행물 정보: 『한국자원식물학회지』제36권 제4호, 257~263쪽, 전체 7쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2023.08.31

영문 초록

Autophagy contributes to enhancing the immune system (innate and adaptive immune system) against foreign pathogens. Autophagy of macrophages is used as a major indicator for developing vaccine adjuvants to increase the adaptive immune response. In this study, water extracts from Rosa acicularis leaves (RAL) increased the production of immunostimulatory mediators and phagocytic activity in RAW264.7 cells. RAL increased p62/SQSTM1 expression. Inhibition of TLR4, JNK, and PI3K/AKT blocked RAL-mediated increase of p62/SQSTM1. RAL activated JNK and PI3K/AKT signaling. RAL-mediated activations of JNK and PI3K/AKT signaling were reversed by TLR4 inhibition. Taken together, it is believed that RAL-mediated autophagy may be dependent on activating via TLR4-dependent activation of JNK and PI3K/AKT signaling in macrophages.

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Conflicts of Interest

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키워드

Autophagy Immunostimulation Macrophages Rosa acicularis Lindl