TEC Genetic Polymorphism is Associated with TNF-α Inhibitor Treatment Response in Rheumatoid Arthritis Patients

• 영문명: TEC Genetic Polymorphism is Associated with TNF-α Inhibitor Treatment Response in Rheumatoid Arthritis Patients
• 발행기관: 대한약학회
• 저자명: Jun Hyeob Kim Woorim Kim Jin Yeon Gil Kyung Hyun Min Ji Min Han Kyung Eun Lee
• 간행물 정보: 『약학회지』제67권 제3호(2023년), 176~181쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.06.30

영문 초록

Numerous genetic and clinical factors influence the progression of rheumatoid arthritis and treatment response. Single nucleotide polymorphisms (SNPs) have been associated with different treatment responses in TNF-α inhibitor users. This study aimed to determine if Tec protein tyrosine kinase (TEC), which belongs to the Tec family of non-receptor protein tyrosine kinases, is associated with treatment response in rheumatoid arthritis (RA) patients. RA patients from three university hospitals were recruited, and clinical data were collected from electronic medical records. One hundred fourteen patients treated with TNF-α inhibitor were included in the analysis. SNP-response associations were evaluated using logistic regression. Among the five SNPs analyzed, rs1472971 and rs11727166 were statistically significant genetic factors of TNF-α inhibitor treatment response. This study provides genetic evidence that TEC polymorphism can be a prognostic marker in treating RA patients.

목차

Introduction

Methods

Results

Discussion

Conclusion

Acknowledgment

Conflict of Interest

References

키워드

Rheumatoid arthritis TNF-α inhibitor Single nucleotide polymorphism Tec protein tyrosine kinase