Lipid-based Liquid Crystalline Phases for Biocompatible and Versatile Drug Delivery

• 영문명: Lipid-based Liquid Crystalline Phases for Biocompatible and Versatile Drug Delivery
• 발행기관: 대한약학회
• 저자명: Sung-Hyun Kim Min-Joon Seo Hyung-sik Lim Jin-Tae Hong
• 간행물 정보: 『약학회지』제67권 제3호(2023년), 137~144쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.06.30

영문 초록

The purpose of the paper was to overview the liquid crystalline phases that can be prepared with various lipids and to assess their characteristics as drug delivery systems for drugs to be administered to various routes. Glyceryl monooleate (GMO) was most frequently employed to deliver the drugs to topical, transdermal, oral, buccal and parenteral routes. In addition to bulk phase such as lamellar and cubic liquid crystalline phases, nano-sized cubosomes of GMO have offered a wide range of chances to administer drugs more precisely to oral and parenteral routes. In addition to GMO different types of lipids including phospholipids, triglycerides, fatty acids and cholesterol were able to form liquid crystalline phases even though most studies employing other lipids than GMO were focused on revealing their phase behaviors and physicochemical characteristics. However, it was expected that more research attempts will be made on utilizing new class of liquid crystalline phases that can be formed with various lipids. Based on the outcome published to date, more versatile drug delivery can be possible if new lipid materials can be developed and used to organize unique molecular orders suitable for a difficult-to-carry drugs.

목차

Introduction

Liquid Crystalline Phases as Drug Delivery Systems

Other Lipids Forming Liquid Crystalline Phases

View on Opportunity in Lipid-based Liquid Crystalline Phases for Drug Delivery

Conclusion

Conflict of Interest

References

키워드

Lipid Liquid crystalline phases Drug delivery Glyceryl monooleate