학술논문
Clinicoepidemiological Profile and Prognostic Factors in Neurotuberculosis in Children
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- 영문명
- Clinicoepidemiological Profile and Prognostic Factors in Neurotuberculosis in Children
- 발행기관
- 대한소아신경학회
- 저자명
- Vikas Sharma Krishnan Rajeshwari Deepak Kumar Garima Gupta
- 간행물 정보
- 『Annals of Child Neurology(구 대한소아신경학회지)』vol.31 no.2, 103~112쪽, 전체 10쪽
- 주제분류
- 의약학 > 소아과학
- 파일형태
- 발행일자
- 2023.04.30
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국문 초록
영문 초록
Purpose: This study aimed to determine the clinicoepidemiological profile and prognostic factors in children with neurotuberculosis.
Methods: An observational study was conducted at a tertiary care hospital on 50 children diagnosed with neurotuberculosis. The demographic profile, clinical details, and all investigations were recorded on a predetermined form and datasheet for analysis, and disability severity was graded using the modified Rankin Scale.
Results: Fifty patients were enrolled (male-to-female ratio, 1.08:1). Younger children (1 to 3 years) were more commonly affected. Most patients were malnourished, and only 58% had been immunized with the Bacillus Calmette-Guerin vaccine. Fever was the most common symptom (96%) followed by headache, altered consciousness, vomiting, seizures, and abnormal posture. On cerebrospinal fluid (CSF) analysis, 87% of patients showed pleocytosis with lymphocytic predominance. More than 80% of patients had CSF protein levels >100 mg/dL and CSF glucose levels <60 mg/dL. Common findings on neuroimaging were hydrocephalus (76%), basal meningeal enhancement (60%), basal exudates (52%), and parenchymal infarcts (32%). We noted a mortality rate of 40%, of whom 87.5% had modified British Medical Research Council (BMRC) stage 3 tubercular meningitis (TBM). All patients who survived stage 3 TBM had a severe disability, and over 50% of patients with stage 2 TBM had moderate to severe disabilities.
Conclusion: Young age, lower socioeconomic status, BMRC stages 2 and 3, abnormal posture, hydrocephalus, and the presence of basal exudates were associated with poor outcomes. High suspicion is needed for early diagnosis and prevention of disability and mortality.
목차
Introduction
Materials and Methods
Results
Discussion
References
해당간행물 수록 논문
- Clinicoepidemiological Profile and Prognostic Factors in Neurotuberculosis in Children
- Clinical Usefulness of a Multiplex Molecular Panel for Central Nervous System Infection: An 11-Month Experience at a Tertiary Center in Korea
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- Identification of Preventable Risk Factors for Developmental Delay in Children: A Pilot Study
- A Case of Acute Disseminated Encephalomyelitis Accompanying Intussusception Associated with Mycoplasma pneumoniae Infection
- Epilepsy of Infancy with Migrating Focal Seizures in a Patient with Nonketotic Hyperglycinemia
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