학술논문
Efficacy and Safety of Lamotrigine Adjunctive Therapy in Lennox-Gastaut Syndrome
이용수 9
- 영문명
- Efficacy and Safety of Lamotrigine Adjunctive Therapy in Lennox-Gastaut Syndrome
- 발행기관
- 대한소아신경학회
- 저자명
- Hui Jin Shin Ara Ko 김세희 이준수 김흥동 강훈철
- 간행물 정보
- 『Annals of Child Neurology(구 대한소아신경학회지)』vol.31 no.2, 91~96쪽, 전체 6쪽
- 주제분류
- 의약학 > 소아과학
- 파일형태
- 발행일자
- 2023.04.30
4,000원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
Purpose: Lamotrigine (LTG) is often used as adjunctive therapy in Lennox-Gastaut syndrome (LGS); however, it may worsen myoclonic and atypical absence seizures in LGS patients. This study reviewed the overall efficacy and safety of LTG in children with LGS.
Methods: This retrospective study included 38 patients (aged <18 years) with LGS who underwent LTG adjunctive therapy between October 2020 and March 2022 at Severance Children’s Hospital. The primary outcome was the change in seizure frequency at 3, 6, and 12 months after starting LTG treatment. A favorable treatment response was defined as a ≥50% reduction in seizure frequency.
Results: The main seizure semiology at the start of treatment was tonic-clonic in 15 (39.5%) patients, spasm in 14 (36.8%), atonic in five (13.2%), myoclonic in three (7.9%), and absence in one (2.6%). The median number of anti-seizure medications (ASMs) was 3.95 (interquartile range, 3 to 4.75). The most common concomitant ASMs were valproate (35/38, 92.1%), levetiracetam (23/38, 60.5%), and topiramate (20/38, 52.6%). After 3 months, seizure frequency was reduced by >50% in 47.4% of patients (18/38). After 6 months, 20 patients (20/36, 55.6%) showed a favorable response. After 12 months, five patients (5/11, 45.5%) responded to treatment. Three patients showed myoclonic seizures at the start of treatment and >50% amelioration in seizure frequency at the 3- and 6-month follow-up visits.
Conclusion: This study reaffirms the efficacy and safety of LTG in children with LGS. Therefore, LTG is strongly recommended as an adjunctive therapy for children with LGS.
목차
Introduction
Materials and Methods
Results
Discussion
References
해당간행물 수록 논문
- Clinicoepidemiological Profile and Prognostic Factors in Neurotuberculosis in Children
- Clinical Usefulness of a Multiplex Molecular Panel for Central Nervous System Infection: An 11-Month Experience at a Tertiary Center in Korea
- Long-Term Pharmacological and Psychosocial Outcomes of Adolescent-Onset Epilepsy: A Single-Center Experience
- A Patient with Doose Syndrome Who Received Low Glycemic Index Treatment
- Efficacy and Safety of Lamotrigine Adjunctive Therapy in Lennox-Gastaut Syndrome
- Complex Febrile Seizures in Children with COVID-19 Infection
- Hypochondroplasia with Acanthosis Nigricans and Moyamoya Disease
- Identification of Preventable Risk Factors for Developmental Delay in Children: A Pilot Study
- A Case of Acute Disseminated Encephalomyelitis Accompanying Intussusception Associated with Mycoplasma pneumoniae Infection
- Epilepsy of Infancy with Migrating Focal Seizures in a Patient with Nonketotic Hyperglycinemia
참고문헌
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!