Ikwi-tang for the treatment of allergic rhinitis as a traditional medicine

• 발행기관: 셀메드 세포교정의약학회
• 저자명: Ji-Hyun Go Jae-Hun Jung Yu-Jung Chang Hyung-Min Kim Yun-Jo Chung
• 간행물 정보: 『셀메드』Volume 3 Issue 1, 1~6쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2013.02.28

영문 초록

Ikwi-tang (IW) is an oriental medicine that has been used for the treatment of general symptoms due to a stomach yin deficiency. The aim of this study is to investigate precisely the effect of IW on allergic rhinitis (AR). We well show the effects and the mechanism of IW in the ovalbumin-sensitized AR model. IW significantly decreased the number of nasal/ear rubs and the increment of IgE levels in the AR mice. The levels of interferon-γ were enhanced while the levels of interleukin (IL)-4 were reduced in the spleen tissue of the IW-administered AR mice. Expressions of IL-1β and cyclooxygenase-2 were inhibited by IW-administration in the nasal mucosa tissues. Infiltration of eosinophils and mast cells was decreased in the IW-administered AR mice. Our results indicate that IW may attenuate the development of AR by the inhibition of caspase-1 activity.

키워드

Ikwi-tang allergic rhinitis IL-1β caspase-1