Anxiolytic-like activity of leaf extract of traditionally used Indian-Mustard (Brassica juncea) in diabetic rats

• 발행기관: 셀메드 세포교정의약학회
• 저자명: Ajit Kumar Thakur Shyam Sunder Chatterjee Vikas Kumar
• 간행물 정보: 『셀메드』Volume 3 Issue 1, 1~7쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2013.02.28

영문 초록

Brassica juncea is a polyphenols enriched edible plant, with diverse medicinal uses of different parts of which have been mentioned in the Ayurveda. The effects of 10 daily oral doses (100, 200, and 400 mg/kg/day) of a methanolic Brassica juncea leaf extract in rat models of anxiety using nondiabetic and alloxan-diabetic rats were quantified. In all the three behavioural tests used, i.e. elevated plus maze, open field, and social interaction tests, anxiolytic-like activity of the extract was observed in the diabetic animals only. Quantitatively, the efficacy of the highest tested dose of the extract in these tests was always less than those observed after its lower ones. These observations provide further experimental evidences for the conviction that Brassica vegetables could as well be useful for combating diabetes associated mental health problems.

키워드

Brassica juncea anxiety comorbidities diabetes mellitus