Inhibitory Effect of Nimbolide on Mast Cell Degranulation and Allergic Asthma in Mice

• 영문명: Inhibitory Effect of Nimbolide on Mast Cell Degranulation and Allergic Asthma in Mice
• 발행기관: 대한약학회
• 저자명: Jung-Eun Lee Dong-Soon Im
• 간행물 정보: 『약학회지』제66권 제5호(2022년), 217~224쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2022.10.31

영문 초록

The Indian neem tree has been used for treating several medical conditions. Nimbolide, an active compound present in the leaves of the Indian neem tree, has shown anti-inflammatory effects in several animal models. However, its efficacy against allergic asthma has not been examined. Therefore, we investigated the effects of nimbolide on mast cell degranulation and ovalbumin-induced allergic asthma in mice. Nimbolide administration inhibited antigen-induced degranulation of RBL-2H3 cells in a concentration-dependent manner and reduced the immune cell numbers by suppressing the expression of inflammatory cytokines, such as IL-4, IL-13, IFN-γ, IL-33, and thymic stromal lymphopoietin (TSLP) in the bronchoalveolar lavage fluid. Histological studies also demonstrated the in vivo efficacy of nimbolide, evident from the reduced number of periodic acid-Schiff-stained cells and inflammatory scores in the lungs. Furthermore, nimbolide administration inhibited the increase of IL-13 levels, but not that of serum IgE levels. These results demonstrate the therapeutic potential of nimbolide against allergic asthma.

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Conflict of Interest

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키워드

Asthma Allergy Neem Nimbolide