OSCC 세포에서 코디세핀이 유도하는 세포자멸사와 EMT 억제효과

• 영문명: Cordycepin Induces Apoptosis and Inhibits EMT in OSCC Cell Lines
• 발행기관: 한국구강보건과학회
• 저자명: 신현철 강해미 박봉수 준두이젬츠 오제렐 김인령
• 간행물 정보: 『한국구강보건과학회지』제10권 제2호, 56~62쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2022.06.30

영문 초록

Objectives: Oral squamous cell carcinoma (OSCC) is an extremely malignant cancer and invades the surrounding tissue in the head and neck region. Cordycepin, also known as 3-deoxyadenosine, is a major compound and has been suggested to have anticancer potential. In this study, we examined the anti-cancer potential of cordycepin as well as its effects on the apoptosis and EMT in Ca9-22 and CAL-27 cells. Methods: The cytotoxicity effects of cordycepin were assessed using an MTT assay. The cell morphology and mitochondrial membrane potential (MMP) changes were monitored using Hoechst and JC-1 dye. Cell cycle arrest was detected using a FACS instrument and the expression of protein level was using a western blot analysis. Results: Cordycepin treated group was significantly induced apoptosis and cell cycle arrest. Also, cordycepin inhibits the EMT in Ca9-22 and CAL-27 cells. Conclusions: Therefore, these results suggest that cordycepin treatment of OSCC cells induced anti-cancer activity.

목차

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 연구결과

Ⅳ. 고찰

Ⅴ. 결론

REFERENCES

키워드

Apoptosis Cordycepin EMT Oral cancer OSCC