Oroxylin A와 관련 유도체 합성 및 효능에 관한 고찰

• 영문명: Review on the Syntheses and Biological Activities of Oroxylin A and Its Derivatives
• 발행기관: 대한약학회
• 저자명: 김예은(Ye Eun Kim) 이상협(Sang Hyup Lee)
• 간행물 정보: 『약학회지』제65권 6호, 405~412쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.12.31

영문 초록

Oroxylin A is a flavonoid compound found in some medicinal plants. Oroxylin A is known to possess a variety of biological properties such as anti-cancer, anti-inflammatory, and neuroprotective effects. In particular, the anti-cancer effect via apoptosis induction and neuroprotective effect through γ-aminobutyric acid type A (GABAA) receptor antagonism are remarkable. Based on this usefulness, extensive efforts to synthesize oroxylin A have been continued. However, semisyntheses using flavone compounds as starting materials rather than total syntheses were mainly conducted, owing to the difficulty of synthesizing oroxylin A. Regarding the semi-synthesis of oroxylinA, several methods using flavone compounds (baicalein, wogonin, or baicalin) were employed to give 8-62% product yields through 3-step reactions. Derivative syntheses were also performed while investigating their biological properties. Therefore, syntheses and biological evaluation of oroxylin A and its derivatives were reviewed to assess and enhance the potential of oroxylin A as a medicinal component.

목차

서 론(Introduction)

Oroxylin A의 효능 및 기작 (Biological activities and mechanisms of oroxylin A)

Oroxylin A의 합성 및 관련 유도체화 (Syntheses and derivatization of oroxylin A)

결론 (Conclusion)

참고문헌

키워드

Oroxylin A Flavonoid Anti-cancer Anti-inflammatory Neuroprotectio