분무건조 방법의 차이가 글리메피라이드 함유 고체분산체의 특성에 미치는 영향

• 영문명: Effect of Spray Drying Method on the Properties of Glimepiride-loaded Solid Dispersion
• 발행기관: 대한약학회
• 저자명: 양현석(Hyun Seok Yang) 오유림(Yu Rim Oh) 김동욱(Dong Wuk Kim)
• 간행물 정보: 『약학회지』제65권 6호, 487~493쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.12.31

영문 초록

Glimepiride (GLI) is a third-generation sulfonylurea class antidiabetic drug that has low aqueous solubility. The objective of this study was to evaluate the effect of solvents in the development of GLI-loaded solid dispersions (GLISD) using spray drying technique. Two GLI-SD were prepared by adding GLI, polyvinylpyrrolidone (PVP K30), and sodium lauryl sulfate (SLS) in an ethanol/water mixture (solvent evaporation, SE) and water only (surface attached, SA). Intrinsic saturated solubilities and in-vitro dissolution were evaluated and compared to the GLI powder and physical mixture (PM). In addition, physicochemical studies such as scanning electron microscopy, differential scanning calorimetry, and X-ray diffraction were also evaluated. We found that the solubility of GLI was significantly improved by both the preparation methods. The SE method showed 4,960-fold improvement while the SA method displayed 2,900-fold enhancement, which is equivalent to the PM. The in-vitro dissolution studies showed that both methods had a higher release rate, about 1.3-fold for SE and 2-fold for SA, as compared to pure GLI powder. However, GLI release slightly decreased with time for the SA method. Furthermore, solid-state characterizations also revealed that most of the crystalline drug was transformed to the amorphous form in both GLI-SD. Thus, these results indicate that choice of the solvent system plays an important role in the spray drying technique which affects the solubility, dissolution, and crystallinity of poorly soluble drugs such as GLI.

목차

서 론(Introduction)

방 법(Methods)

결과 및 고찰(Results and Discussion)

결 론(Conclusion)

References

키워드

Glimepiride Polyvinyl pyrrolidone Sodium lauryl sulfate Solid dispersion Solvent evaporation method Surface attached method Spray dryer