수 종 대사증후군 개선약물이 포볼 에스터 및 상피세포 성장인자로 유발된 기도 MUC5AC 뮤신 유전자 발현 및 생성에 미치는 영향

• 영문명: Effects of Several Drugs for Metabolic Syndrome on Phorbol Ester- or Epidermal Growth Factor-induced Gene Expression and Production of Airway MUC5AC Mucin: Investigation of Potential Regulator for Hypersecretion of Airway Mucus using Drug Repositioning Strategy
• 발행기관: 대한약학회
• 저자명: 이현재(Hyun Jae Lee) 이충재(Choong Jae Lee)
• 간행물 정보: 『약학회지』제65권 6호, 424~431쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.12.31

영문 초록

We investigated whether rosiglitazone, metformin, thioctic acid, simvastatin, or glimepiride affects airway MUC5AC mucin gene transcription or protein expression induced by phorbol 12-myristate 13-acetate (PMA) or epidermal growth factor (EGF) in NCI-H292 cells. Cells were pretreated with each agent for 30 min, then stimulated with PMA or EGF for 24 h. Of the five agents, rosiglitazone inhibited PMA-induced gene transcription and production of MUC5AC mucin in NCI-H292 cells. This result suggests that rosiglitazone, an antidiabetic peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, can inhibit PMA-induced mucin expression at mRNA and protein levels, through directly acting on airway epithelial cells.

목차

서 론(Introduction)

방 법(Methods)

결과 및 고찰(Results and Discussion)

결 론(Conclusion)

References

키워드

Airway mucin Rosiglitazone Metformin Thioctic acid Simvastatin Glimepiride