카나비노이드 수용체 활성화 및 TRPV1 억제를 통한 arachidonoyl-serotonin (AA-5-HT)의 진통 효과

• 영문명: Antinociceptive Effects of Arachidonoyl-serotonin (AA-5-HT) by Activation of Cannabinoid Receptor and Inhibition of TRPV1
• 발행기관: 대한약학회
• 저자명: 심은진(Eunjin Sym) 심원식(Won-Sik Shim)
• 간행물 정보: 『약학회지』제65권 제4호(2021년), 237~245쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.08.31

영문 초록

Pain is a noxious sensation caused by tissue damage, which can severely interfere with a person’s quality of life. Although numerous analgesics are available for eradicating pain, there remain limitations in terms of safety and efficacy. This review focuses on arachidonoyl-serotonin (AA-5-HT) − an endogenous lipid with a putative antinociceptive effect. After detailed investigation, previous studies have revealed that AA-5-HT can stimulate the cannabinoid system, which results in the inhibition of pain sensation. Moreover, AA-5-HT can inhibit the action of TRPV1, which is a nonselective cation channel that mediates pain signals in the nervous system. This dual effect makes AA-5-HT a potentially safe and potent analgesic. This review summarizes the roles of the cannabinoid system and TRPV1 in pain sensation, and the function of AA-5-HT in pain modulation.

목차

서 론(Introduction)

통증의 분자생물학적 기전

AA-5-HT의 통증 억제 기전

결 론(Conclusion)

감사의 말씀(Acknowledgment)

Conflict of Interest

References

키워드

Arachidonoyl-serotonin (AA-5-HT) Cannabinoid Anandamide FAAH TRPV1 Pain