피리다진계 항당뇨 화합물의 합성 및 평가

• 영문명: Synthesis and Evaluation of Pyridazine Analogs as Potential Antidiabetic Agents
• 발행기관: 대한약학회
• 저자명: 보두이비엣(Duy-Viet Vo) 박해일(Haeil Park)
• 간행물 정보: 『약학회지』제65권 제4호(2021년), 331~334쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.08.31

영문 초록

3,6-Disubstituted pyridazine analogs (2a and 2b) were synthesized from commercially available 3,6- dichloropyridazine in two steps. The synthesized compounds were evaluated for their GPR119 agonistic activity. Both compounds exhibited much stronger EC50 values than that of oleylethanolamide (OEA) and were proved to be partial agonists. These results indicate that the pyridazine ring can be used as a potential heterocycle scaffold for GPR119 agonists.

목차

서 론(Introduction)

방 법(Methods)

결과 및 고찰(Results and Discussion)

결 론(Conclusion)

감사의 말씀(Acknowledgment)

Conflict of Interest

References

키워드

GPR119 agonists Antidiabetic agents Fragment structure Bioequivalent Pyridazine analogs Lead compounds