율피 추출물에 의한 Tyrosinase 활성억제 및 Melanin 생성억제 효과

• 영문명: Inhibitory Effects of Chestnut Bark Extracts on Tyrosinase Activity and Melanin Biosynthesis
• 발행기관: 한국환경보건학회
• 저자명: 양민진(Min Jin Yang) 임세진(Se Jin Lim) 안형수(Hyung Soo Ahn) 김명애(Myoung Ae Kim) 안령미(Ryung Me Ahn)
• 간행물 정보: 『1. 한국환경보건학회지』제25권 제1호, 37~43쪽, 전체 7쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 1999.03.30

영문 초록

The inhibitory effects of chestnut bark extracts (CIS, CIS-gel, CIS jelly) were investigated in vitro and in B-16 mouse melanoma cells on melanin biosynthesis which is closely related to hyperpigmentation. These extracts inhibited tyrosinase activity which converts dopa to dopachrome in the biosynthetic process and the extracts inhibited the production of melanin from dopachrome by auto-oxidation. B-16 cells treated by chestnut bark extracts showed that the viability was over 85% in MTT assay. Melanin production was inhibited significantly by chestnut bark extracts in vitro and in B-16 cells. Especially CIS showed 15 times stronger inhibition of melanin production than kojic aicd in vitro. CIS-gel and CIS showed much stronger inhibition of melanin production under concentration of 4 ㎍/㎖ than kojic acid in B-16 cells. These results suggest that the chestnut bark extracts can be used for a whitening agent of the skin.

목차

I. 서론

II. 재료 및 방법

III. 결과

IV. 고찰

V. 결론

키워드

Chestnut bark extracts Tyrosinase Dopachrome Melanin