인체용 항생제의 우선관리대상 선정과 물환경 중 오염농도 추정

• 영문명: Prioritizing human use antibiotics for environmental health management and estimating theirenvironmental concentrations in Korean waterway
• 발행기관: 한국환경보건학회
• 저자명: 김명현(Myung Hyun Kim) 박정임(Jeongim Park) 김영희(Young Hee Kim) 최경호(Kyungho Choi)
• 간행물 정보: 『1. 한국환경보건학회지』제32권 제5호, 462~468쪽, 전체 7쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2006.10.30

영문 초록

Antibiotics are manufactured and used for specific physiological functions, hence they may exert adverse ecological consequences when they are in contact with nontarget organisms. In the last decade, many reports have been made on the occurrences of various antibiotic compounds in surface water, and their potential impact to the environment has become an increasing concern. This study was conducted to prioritize antibiotic substances with potential environment risk in Korea. Human use antibiotics with an EIC (Expected Introduction Concentration) value greater than 1 mg/l, US FDA s action limit criteria, were selected. In order to calculate a worst-case EIC for each substance, annual production volume (in kg) of each antibiotic substance was derived using the Korea Pharmaceutical Manufacturers Association (KPMA) s monetary database. Sixteen substances were preliminarily selected. The EICs of the 16 antibiotic substances were refined with the excretion rate of the parent substances. Ten antibiotic substances were identified to have EICcorrected greater than 1 mg/l, which include Amoxicillin (15.8 mg/l), Cefaclor (10.1 mg/l), Roxithromycin (4.2 mg/l), Cephradine (4.5 mg/l), Cefatrizine (2.6 mg/l), Cefadroxil (3.3 mg/l), Aztreonam (2.3 mg/l), Ceftazidime (2.8 mg/l), Ribostamycin (1.3 mg/l), and Ceftezole (1.3 mg/l). Additional risk assessments for these antibiotic substances are suggested.

목차

Ⅰ. 서론

Ⅱ. 연구대상 및 방법

Ⅲ. 결과 및 고찰

Ⅳ. 결론

키워드

pharmaceuticals in the environment expected introduction concentration antibiotics prioritization production volume