Cefotaxime을 이용한 PVA/PAA 하이드로 겔 필름의 항균 특성

• 영문명: Antibacterial Characteristics of PVA/PAA Hydrogel Film using Cefotaxime
• 발행기관: 한국환경보건학회
• 저자명: 염석재(SeokJae Yeom) 정선도(Sundo Jung) 오은하(Eunha Oh)
• 간행물 정보: 『1. 한국환경보건학회지』제47권 제1호, 55~63쪽, 전체 9쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2021.02.28

영문 초록

Objectives: Cefotaxime is an antibiotic used to treat several bacterial infections. Specifically, it is used to treat pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, and sepsis. It is given by injection into either a vein or muscle. Antibacterial polymers prepared by chemical bonding and simple blending of antibacterials into polymers has attracted much interest because of their long-lasting antibacterial activity. This study attempted to review the possibility of hydrogel films as functional antibacterial materials by antimicrobial activity. Methods: In this study, CTX-PAA was synthesized by the chemical reaction of polyacrylic acid with cefotaxime by N,N -Dicyclohexylcarbodiimide (DCC) method. Synthetic antibacterial hydrogel films were then prepared with PVA and CTX-PAA for functional application. Results: The increase in the cefotaxime content of the hydrogel films showed a similar decrease in tensile strength and elongation. The values of films impregnated with chemically bonded cefotaxime showed no significant difference. Antibacterial susceptibility was determined against Streptococcus pneumoniae and Escherichia coli using a standardized disc test. Conclusion: The synthetic antibacterial hydrogel films exhibited broad susceptibility against Streptococcus pneumoniae and Escherichia coli. Notably, the antibacterial effect of antibacterial hydrogel films against Gram-positive (Streptococcus pneumoniae) was superior to that against Gram-negative (Escherichia coli).

목차

I. 서 론

II. 재료 및 방법

III. 결과 및 고찰

IV. 결 론

키워드

Antibacterial characteristics hydrogel film cefotaxime DCC method cephalosporins