아인산염 처리에 따른 철원양파의 페놀화합물 비교 분석 연구

• 영문명: Comparative Study on Cheorwon Onion Phenolic Compounds by Phosphate Treatment
• 발행기관: 한국자원식물학회
• 저자명: 김연복(Kim, Yeon Bok) 이희종(Lee, Hee Jong) 김동현(Kim, Dong Hyun) 박철호(Park, Cheol Ho) 장광진(Jang, Kwang Jin)
• 간행물 정보: 『한국자원식물학회 학술심포지엄』2018년도 추계학술대회, 107~107쪽, 전체 1쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2018.10.31

영문 초록

In this study, we evaluated the anti-cancer effect of extracts of leaves (ST-L) and branches (ST-B) from Sageretia theezans in human colorectal cancer cells. ST-L and ST-B significantly inhibited the proliferation of human colorectal cancer cells, SW480. ST-L and ST-B decreased cyclin D1 protein level through the induction of cyclin D1 proteasomal degradation via $GSK3{\beta}$-dependent threonine-286 phosphorylation of cyclin D1. In addition, ST-L and ST-B increased HO-1 protein through p38, ROS and $GSK3{\beta}$-dependent Nrf2 activation. These findings suggest that ST-L and ST-B may have great potential for the development of anti-cancer drug to treat human colorectal cancer.

키워드

Anti-cancer Human colorectal cancer Sageretia theezans