동의보감 무운산 처방 추출물의 생리활성 비교

• 영문명: Comparative Analysis of Physiological Activities of Muunsan Extract from the Donguibogam
• 발행기관: 한국인체미용예술학회
• 저자명: 김유라(Yu-Ra Kim) 이재숙(Jea-Sook Lee)
• 간행물 정보: 『한국인체미용예술학회지』한국인체미용예술학회지 제20권 제4호, 57~68쪽, 전체 12쪽
• 주제분류: 예술체육 > 예술일반
• 파일형태: PDF
• 발행일자: 2019.12.20

영문 초록

This study investigated the usability of muunsan in the Donguibogam (Korean Medical Encyclopedia) as a cosmetic material by analyzing its physiological activities. In terms of total phenol contents, MUSD and MUSE were 234.34±0.59 ㎎/g and 429.21±1.55 ㎎/g, respectively. It was confirmed that it has poly-phenolic compounds, which are similar to the reference material ‘tannic acid’. According to the measurement of antioxidant efficacies, MUSD and MUSE were 89% and 96% each at 500㎍/㎖ in terms of DPPH radical scavenging activity. In terms of ABTS radical scavenging activity, MUSD and MUSE were 70% or higher and 80% or higher at 1,000㎍/㎖, showing antioxidant effects similarly to that of Vit-C. In ROS production, MUSD and MUSE revealed a significant decrease (***p<0.001, **p<0.01, *p<0.05) at 50, 100 ㎍/㎖ and 10, 50, 100 ㎍/㎖ respectively. In cytotoxicity, cell viability was 85% or higher up to 500 ㎍/㎖, confirming no toxicity. In terms anti-inflammatory effects, nitric oxide production decreased up to 500 ㎍/㎖. According to a western blot, when the extract was processed by concentration, protein expression declined in a dose-dependent manner. In antimicrobial activity, as the extract got more concentrated, antimicrobial activity increased, confirming antimicrobial effects. The above results show that muunsan extract can be used in manufacturing cosmetics as a natural substance with antioxidant, anti-inflammatory and antimicrobial effects.

목차

Ⅰ. 서론

Ⅱ. 실험 방법

Ⅲ. 실험결과

Ⅳ. 결론

키워드

무운산추출물 한약재복합추출물 항산화 항균활성 항염 효과 Muunsan Extract Medicinal Herb Complex Extract Anti-oxidation Antimicrobial Activity Anti-inflammatory Effects