한국산 헛개나무 가지 열수추출물의 파골세포 분화 억제

• 영문명: Effects of Hovenia dulcis var. Koreana Extracts in Osteoclast Differentiation
• 발행기관: 대한약학회
• 저자명: 김광진(Kwang-Jin Kim) 이용진(Yongjin Lee) 강경윤(Kyung-Yun Kang) 이성태(Sung-Tae Yee) 남상집(Sang-Jip Nam) 이미경(Mi-Kyung Lee) 이미자(Mi-Ja Lee) 손영진(Young-Jin Son)
• 간행물 정보: 『약학회지』제62권 제6호(2018년), 388~393쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2018.12.31

영문 초록

Osteoporosis is a disease characterized by a decrease in bone mineral density and an increase in fracture rate. One of the most related to bone density in osteoporosis is osteoclast. Osteoclasts, the only cells that resorbing bone, are a key mediator of skeletal disease such as osteoporosis. Therefore, one of the most influential methods for treating bone diseases with reduced bone mass is inhibiting osteoclast formation and activation. In previous studies, we reported that Hovenia dulcis var. Koreana extracts (HD) inhibits osteoclast differentiation and is effective in the prevention of osteoporosis in vivo. However, we did not disclose how HD works during osteoclast differentiation. Herein, we investigated the mechanisms of anti-osteoclastogenic activity of HD on osteoclast differentiation in vitro. HD inhibited RANKL-mediated osteoclast differentiation of cultured BMMs in a dose-dependent manner and did not exert a cytotoxic effect on BMMs. HD suppressed transcriptional and translational expression of NFATc1 as well as osteoclast-related genes such as TRAP, DCSTAMP, and cathepsin K in BMMs treated with RANKL. Taken together, these results suggest that HD may influence the expression levels of NFATc1 and osteoclast-specific genes during osteoclast differentiation. Therefore, HD may be usefully used as a functional food or a therapeutic agent for bone diseases such as osteoporosis.

목차

서 론(Introduction)

실험 방법(Experimental Methods)

결 과(Results)

고 찰(Discussion)

결 론(Conclusion)

키워드

bone osteoporosis osteoclast RANKL NFATc1 Hovenia dulcis