랫트 및 돼지 체내에서 후라졸리돈의 환원대사에 관한 연구

• 영문명: A Study of Reductive Metabolism of Furazolidone by Rat and Swine Tissues
• 발행기관: 한국예방수의학회
• 저자명: Jong Myung Park(朴鍾鳴) Young Hwa Sim(沈暎和) In Cheon Kim(金仁千) Nam Seop Jin(鎭南燮) Mun Han Lee(李文漢)
• 간행물 정보: 『Korean Journal of Veterinary Public Health』Vol.19, No.1, 81~88쪽, 전체 8쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 1995.06.30

영문 초록

The reductive metabolism of an antibacterial nitrofuran, furazolidone[N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone] was investigated. E. coli rapidly metabolized furazolidone to the reduced cyano metabolite under aerobic condition. The major solvent-extractable metabolite produced under the aerobic incubation was isolated and analyzed by mass spectrometry. The mass spectra indicated that this metabolite was unequivocally identified as 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone, an end product of the reductive metabolism of the nitro group of furazolidone. When furazolidone was administered orally to rats and piglets, 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone was isolated and purified from the muscle, kidney and liver tissues according to the withdrawal time. These purified extracts were analyzed by high performance liquid chromatography(HPLC).

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E. coli furazolidone 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone HPLC Rat Swine Liver Kidney Muscle