채혈 방법에 따른 혈액상 변화 연구

• 영문명: Response of Some Blood Parameters to Sampling Technique in Rats
• 발행기관: 한국예방수의학회
• 저자명: 장동덕(Dong Deuk Jang) 신동환(Dong Hwan Shin) 최진영(Jin Young Choi) 홍충만(Choong Man Hong) 조재천(Jae Chon Cho) 한익수(Ik Su Han)
• 간행물 정보: 『Korean Journal of Veterinary Public Health』Vol.19, No.1, 75~80쪽, 전체 6쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 1995.06.30

영문 초록

Clinical pathology testing in non-clinical toxicity and safety studies is an important part of safety assessment. We sought to study if there were any difference in the results of clinical pathology tests among orbital venous plexus(OVP), heart and posterior vena cava(PVC) in rats anesthertized with CO₂ and ether. White blood cell counts was significantly higher in blood samples collected from OVP as compared with heart. Total protein and glucose were significantly higher in rats anesthetized with ether as compared with rats with CO₂. Comparing the bleeding sites and anesthesia in non-clinical toxicity test, drawing blood from OVP in the rats under CO₂ anesthesia was reliable method.

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Clinical pathology Bleeding sites Anesthesia Rat