돼지열병백신 (LOM-850)의 접종 경로에 따른 면역 반응

• 영문명: Immune responses according to the different inoculation routes of classical swine fever vaccine (LOM-850)
• 발행기관: 한국예방수의학회
• 저자명: 이오수(O Soo Lee) 탁동섭(Dong Seob Tark) 양동군(Dong Kun Yang) 김병한(Byoung Han Kim) 윤순식(Soon Seek Yoon) 안수환(Soo Hwan An) 전무형(Moo Hyung Jun)
• 간행물 정보: 『Korean Journal of Veterinary Public Health』Vol.32, No.1, 69~80쪽, 전체 12쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2008.06.30

영문 초록

This study was performed to evaluate the difference of immunity obtained by the inoculation routes of classical swine fever virus (CSFV) vaccine (LOM-850). Two month-old piglets, which were antibody negative or had 1:2 to 1:4 maternal antibodies to CSFV, were intraocularly inoculated once with the vaccine virus strain LOM-850 (106.0TCID50/ml) and challenged at 2 weeks later with the virulent ALD strain. The piglets showed clinical and histopathological signs of CSF and also did not obtain immunity. However the antibody levels of protective immunity were obtained when the other piglets were vaccinated two times at 2 weeks interval via intraocular route. But the piglets with 1:32～1:128 maternal antibody titers were not fully boosted to the levels of the protective immunity to CSFV after 2 intraocular inoculations because of the interference of maternal antibodies. To compare the level of immunity to intranasal with intraocular vaccination route, two month-old piglets were intranasally inoculated once with 0.65 ml of LOM-850(106.0TCID50/ml). After two weeks of vaccination, antibody levels rose from 1:16 to 1:256 and the protective immunity to highly pathogenic ALD strain (105.5TCID50/ml) was developed in the piglets. In conclusion, intranasal inoculation route was better than intraocular route to induce the protective immunity of LOM-850 vaccine to CSFV in piglets.

목차

서 론

재료 및 방법

결 과

고 찰

참고문헌

키워드

CSFV LOM-850 vaccination intraocular intranasal immunity