우유에서의 클로람페니콜 잔류 소실 양상

• 영문명: Residue depletion profile of chloramphenicol in milk
• 발행기관: 한국예방수의학회
• 저자명: 임채미(Chae Mi Lim) 조병훈(Byung Hoon Cho) 서국현(Guk Hyun Suh) 강성진(Seog Jin Kang) 허태영(Tai Young Hur) 박수정(Su Jeong Park) 권현정(Hyun Jeong Kwon) 정갑수(Gab Soo Chung)
• 간행물 정보: 『Korean Journal of Veterinary Public Health』Vol.32, No.1, 55~59쪽, 전체 5쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2008.06.30

영문 초록

The residue depletion profile of chloramphenicol from milk was studied after intramuscular injection (IM) milking cow. The drug was administered as a single dose of 10 mg chloramphenicol per kg (body weight) twice a day for 3 consecutive days. Milks were collected before, during and after treatment. The chloramphenicol concentrations in milk were quantified by liquid chromatography-tandem mass spectrometry. Chloramphenicol concentration measured on the first day after the last dose peaked at 313.6 ng/g in milk. The drug residual levels were declined gradually, 0.4 ng/g in milk detected at 5 days after the final dose. The chloramphenicol residue levels in milk dropped to below the EU minimum required performance limit (EU MRPL 0.3 ng/g) on the 6th day of withdrawal of the drug.

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chloramphenicol LC-MS/MS milk residue depletion