PCR법을 이용한 국내 분리 캠필로박터균에서 Guillain-Barre Syndrome 관련 galE 유전자 검출에 관한 연구

• 영문명: Original Article : Detection of galE gene in Campylobacter spp. associated with Guillain-Barre syndrome using polymerase chain reaction
• 발행기관: 한국예방수의학회
• 저자명: 구복경(Bok Kyung Ku) 김혜지(Hae Ji Kim) 김영일(Young Il Kim) 최정수(Jung Soo Choi) 박미영(Mi Young Park) 권진욱(Jin Wook Kwon) 김용환(Yong Hwan Kim) 김종현(Jong Hyun Kim) 이영주(Young Joo Lee) 김은경(Eun Gyeong Kim)
• 간행물 정보: 『Korean Journal of Veterinary Public Health』Vol.34, No.3, 189~195쪽, 전체 7쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2010.09.30

영문 초록

Guillain-Barre syndrome (GBS) is the most common cause of acute flaccid paralysis and autoimmune polyradiculo-neuropathy. Campylobacter jejuni is the most commonly identified infectious trigger for GBS. A sialic-acid containing lipopolysaccharide (LPS) of Campylobacter is thought to be involved in the triggering of GBS. The galE (UDP-galactoset-epimerase) gene of Campylobacter spp. is involved in the synthesis of LPS. In this study, we detected the galE gene in Campylobacter spp. responsible for triggering the onset of GBS. The PCR assay detected the presence of the gene in 14 of the 25 (56%) Campylobacter isolates from domestic chicken, 20 of the 28 (71.4%) Campylobacter isolates from imported chicken and 50 of the 51 (98%) Campylobacter isolates from human clinical samples. Also, the specific 497-bp region of galE sequence in Campylobacters responsible for triggering the onset of GBS was amplified from GBS patient. These results could provide evidence of the first GBS-related C. jejuni infection in Korea.

목차

Introduction

Materials and Methods

Results

Discussion

References

키워드

Campylobacter GBS galE Gene