저선량 감마선 조사 마우스의 말초면역 세포에 대한 바나듐 함유, 제주 워터의 면역 활성 효과

• 영문명: Original Article : Immune activation of Jeju water containing vanadium on peripheral immunocytes, of Low dose gamma rays-irradiated mice
• 발행기관: 한국예방수의학회
• 저자명: 하단비(Dan Bee Ha) 김민주(Min Ju Kim) 주해진(Hae Jin Joo) 조진희(Jin Hee Cho) 빙소진(So Jin Bing) 임윤규(Yoon Kyu Lim) 현진원(Jin Won Hyun) 지영흔(Young Heun Jee)
• 간행물 정보: 『Korean Journal of Veterinary Public Health』Vol.35, No.1, 49~59쪽, 전체 11쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2011.03.30

영문 초록

Vanadium, a dietary micronutrient, has been reported to present interesting biological and pharmacological properties, including superoxide and nitric oxide scavenging effects. Low-dose ionizing radiation (LDR) is known to damage DNA and cause apoptosis of peripheral immunocytes by producing reactive oxygen species (ROS). The aim of this study was to elucidate the capacity of immune activation of Jeju water containing vanadium on immunosuppression caused by LDR. We examined the ROS production, DNA damage, cell apoptosis and proliferation of peripheral immunocytes in irradiated mice drinking different concentrations for 90 days; V0 (vanadium 0㎍/L, control), V1 (vanadium 15~20㎍/ L) and V2 (vanadium 20∼25㎍/L). Compared to V0 control where level of ROS showed tendency to increase, the ROS production was attenuated in peripheral immunocytes of irradiated mice drinking V1 and V2. DNA damage of peripheral immunocytes triggered by LDR significantly increased in mice drinking V0 compared to non-irradiated control, whereas V1 and V2 dramatically induced remission of DNA damage. On the observation of apoptosis of peripheral immunocytes, V1 and V2 showed the potency to reduce the number of apoptotic cells. On the other hand irradiated mice drinking V0 exhibited raised number of apoptotic cells. From the results obtained, we speculated that Jeju water containing vanadium (V1 and V2) has a potential role in decreasing DNA damage and apoptosis of immune cell by inhibiting ROS production. Consistent with this, Jeju water containing vanadium (V1 and V2) exhibits a capacity to enhance cell proliferation of peripheral immunocytes, which is suppressed by LDR as shown in V0 control. Collectively, Jeju water containing vanadium reduced DNA damage and apoptosis and induced the stimulatory potential on immunocytes. Theseresults suggest that Jeju water containing vanadium sustained immune activities under immunosuppression caused by LDR.

키워드

Jeju Water Vanadium Immune Activation