기억성 경도인지장애 환자에서 알츠하이머병 치매로의 진행과 신경정신행동 증상

• 영문명: Neuropsychiatric Symptoms and Increased Risks of Progression from Amnestic Mild Cognitive Impairment to Alzheimer’s Dementia
• 발행기관: 대한노인정신의학회
• 저자명: 신 진(Jin Shin) 유승호(Seung Ho Ryu) 하지현(Jee Hyun Ha) 박두흠(Doo Heum Park) 유재학(Jae hak Yu)
• 간행물 정보: 『노인정신의학』노인정신의학 제21권 제1호, 29~34쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2017.04.30

영문 초록

Objective：Neuropsychiatric symptoms (NPS) are common in dementia and in mild cognitive impairment (MCI). They might be a predictor of progression to dementia. This study aimed to investigate the effects of NPS on the natural course in MCI. Methods：306 community-dwelling Korean elderly with MCI from local dementia center were assessed for NPS using Neuropsychiatric Inventory (NPI). Subjects were assessed again after more than a year from baseline. 52 subjects (17.0%) were progressed to dementia. We compared baseline NPI scores between stable and deteriorated groups. Results：Subjects progressing to dementia had a significantly higher prevalence of NPS (45.3% vs. 65.4%) than subjects who remained stable. Delusion (2.8% vs. 9.6%), agitation/aggression (14.6% vs. 26.9%), depression (21.7% vs. 40.4%) and disinhibition (4.3% vs. 19.2%) were more common in deteriorated group. After adjustment for other variables, on logistic regression analysis, only disinhibition at baseline was shown to be a risk factor for progression to dementia (OR=4.88, 95% CI=1.37-17.36, p=0.01, R2=302). Conclusion：These findings suggest that NPS in MCI may be a predictor of progression to dementia. NPS may be a useful item including delusion, agitation/aggression, depression, and disinhibition. To study course and nature of NPS may lead to better understanding of Alzheimer’s disease.

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키워드

Neuropsychiatric symptoms Mild cognitive impairment Alzheimer’s disease Disinhibition 신경정신행동 증상 경도인지장애 알츠하이머병 탈억제