음경해면체 평활근의 이완에 대한 인진쑥으로부터 유래한 Esculetin의 효과

• 영문명: Effect of Esculetin from Artemisia capillaris on the Relaxation of Penile Corpus Cavernosum Smooth Muscle
• 발행기관: 대한약학회
• 저자명: 김혜경(Hye Kyung Kim)
• 간행물 정보: 『약학회지』제61권 제1호(2017년), 48~54쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.02.28

영문 초록

The purpose of this study was to evaluate the relaxant effect and action mechanism of esculetin from Artemisia capillaris on penile corpus cavernosum smooth muscle (PCCSM). Esculetin (10-7, 10-6, 10-5 and 10-4 M) induced PCCSM relaxation in a concentration-dependent manner. The pretreatment with nitric oxide synthase inhibitor (Nω-Nitro-L-arginine methyl ester, L-NAME) and guanylate cyclase inhibitor (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, ODQ) significantly blocked the relaxation. Esculetin significantly increased level of cGMP in perfusate and enhanced phosphodiesterase type 5 inhibitors (PDE5 Is)-induced relaxation in PCCSM. Esculetin relaxed the smooth muscle of rabbit penile corpus cavernosum by activating NO-cGMP signaling pathway and it may be an alternative medicine or supplement for improving erectile dysfunction in patients who do not completely respond to PDE5 Is.

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키워드

Artemisia capillaris esculetin penile corpus cavernosum smooth muscle (PCCSM) phosphodiesterase type 5 inhibitors (PDE5 Is) NO-cGMP signaling pathway