벤조[b][1,4]옥사진-3(4H)-치온 유도체의 합성과 이들의 타이로시네이즈 저해 활성

• 영문명: Synthesis of Benzo[b][1,4]oxazine-3(4H)-thione Derivatives and Their Anti-tyrosinase Activity
• 발행기관: 대한약학회
• 저자명: 김도현(Do Hyun Kim) 천부순(Pu soon Chun) 정해영(Hae Young Chung) 문형룡(Hyung Ryong Moon)
• 간행물 정보: 『약학회지』제61권 제1호(2017년), 6~11쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.02.28

영문 초록

To investigate whether a “β-phenyl-α,β-unsaturated thiocarbonyl” scaffold can play a key role in tyrosinase inhibition, benzo[b][1,4]oxazine-3(4H)-thione derivatives bearing the scaffold were synthesized through a three-step reaction including Knoevenagel condensation. Four compounds showed not only high binding affinity with tyrosinase on docking simulation but also greater inhibitory activity against mushroom tyrosinase than arbutin. These results indicate that a “β- phenyl-α,β-unsaturated thiocarbonyl” may serve as an important chemical scaffold for potent tyrosinase inhibitors.

목차

재료 및 실험 방법

실험결과 및 고찰

결과 및 고찰

감사의 말씀

References

키워드

thiocarbonyl tyrosinase benzoxazinethione arbutin docking simulation