페닐피리딜부테노이드 이량체의 합성 및 일산화질소 생성 억제작용

• 영문명: Synthesis of Phenylpyridylbutenoid Dimers and their Inhibitory activity against NO Production
• 발행기관: 대한약학회
• 저자명: 방원영(Yuan ying Fang) 박해일(Hae il Park)
• 간행물 정보: 『약학회지』제60권 제6호(2016년), 285~289쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2016.12.30

영문 초록

Several naturally occurring phenylbutenoid dimers were reported to possess anti-inflammatory activity. Three phenylpyridylbutenoid dimers(#1, #2 and #3) were synthesized and evaluated for their inhibitory activities against NO production from LPS-induced RAW 264.7 cells. None of the tested phenylpyridylbutenoid dimers showed any inhibitory activity against NO production, exhibiting cytotoxicity at a concentrated(100 μM) dose. These results imply that substitution of the benzene ring-A of the natural phenylbutenoid dimer(R=OMe) to a less hydrophobic pyridyl group results in loss of bioactivity.

목차

Abstract

재료 및 방법

실험결과 및 고찰

결론

감사의 말씀

References

키워드

phenylpyridylbutenoid dimers anti-inflammatory nitric oxide(NO) production