다형성 선종에서 발생한 구개부의 상피성-근상피암종

• 영문명: EPITHELIAL-MYOEPITHELIAL CARCINOMA ARISING IN PLEOMORPHIC ADENOMA OF PALATE
• 발행기관: 대한구강악안면외과학회
• 저자명: 김경욱(Kyung-Wook Kim) 한세진(Se-Jin Han)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제33권 제5호, 479~484쪽, 전체 6쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2007.10.30

영문 초록

A case of epithelial-myoepithelial carcinoma transformed in pleomorphic adenoma occurring in palate of a 61 years old woman is reported. The tum or was composed of 2 different components, pleomorphic adenoma and epithelial myoepithelial carcinoma, accounting for approximately 40% and 60 % of whole tumor, respectively. As the results of the immunohistopathologic study, epithelial-myoepithelial carcinoma showed multiple tubular or solid nest, which were separated by a basement membrane and considered of variable proportion of 2 cell types, cuboidal epithelial cells positive for cytokeratin and clear myoepithelial cells positive for glial fibrillary acid protein, wheres the myoepithelial nest of pleomorphic adenoma intermingled with hyaline and myxoid str oma. The malignancy was demonstrated by convincing evidence of invasion into the submucosa, although the epithelial-myoepithelial carcinoma com ponent was mostly surrounded by the pleomorphic adenoma componemts. An increased immunoreactivity of proliferating cell nuclear antign in the ep ithelial myoepithelial carcinoma area in comparison to the pleomorphic adenoma also suggested epithelial-myoepithelial carcinoma arising in a pleomorphic adenoma.

키워드

Epithelial-myoepithelial carcinoma Pleomorphic adenoma Immunohistopathologic study