나노 에멀젼이 잇몸 염증의 예방 및 치료에 미치는 효과에 대한 연구

• 영문명: THE STUDY ON THE EFFECT OF NANOEMULSION FOR THE PREVENTION AND TREATMENT OF GINGIVAL INFLAMMATION
• 발행기관: 대한구강악안면외과학회
• 저자명: 채창훈(Chang-Hoon Chae) 박준우(Jun-Woo Park)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제33권 제5호, 419~425쪽, 전체 7쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2007.10.30

영문 초록

We have found out the relationship of nanoemulsion containing nano vitamin C, E and propolis and gingival disease. We’ve confirmed effect of nanoemulsion through the experiment of in vivo and in vitro. We tested cell viability of gingival fibroblast cells by MTT assay and mRNA appearance of interleukin-1β, using mouse that was guided inflammation. Anti-microbacterial activity for Antibacterial effect’s experiment was carried out by using S.aureus and E.coli. In addition, inflammation tissue has been observed with scanning electrical microscopy. In this study, expression of interleukin-1βwas decreased after adding nanoemulsion containing nanovitamin C, E and propolis. We’ve also obtained good results from the test of Antibacterial effect against S.aureus and E.coli. Also, swelling of inflammation tissues observed by scanning electrical microscopy has gone down. In conclusion, we have gained confidence that nanoemulsion containing nano vitamin C, E and propolis has very high Antibacterial effect against bacteria in oral. And it made us guess that inflammation of gingival reduces after decreasing interleukin-1β. Thus, we expect that nanoemulsion containing nano vitamin C, E and propolis gives good effects to patient having gingival disease.

키워드

Inflammation Nano-vitamin C E Propolis Interleukin-1β Gingival fibroblast cell