인체상피세포를 이용한 Vinyl acetate의 발암성 및 작용기전

• 영문명: HIGH DOSE EXPOSURES OF VINYL ACETATE INDUCE NEOPLASTIC TRANSFORMATION OF HUMAN EPITHELIAL CELLS IN CULTURE
• 발행기관: 대한구강악안면외과학회
• 저자명: 조준현(Jun-Hyun Cho) 김진수(Chin-Soo Kim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제33권 제5호, 437~444쪽, 전체 8쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2007.10.30

영문 초록

Vinyl acetate has been widely used for the manufacture of polyvinyl alcohol emulsion, which is primary ingredient of adhesive, paints, textile, paperboard coatings, etc. Since these products are plentiful and frequently used around us, workers and consumers are at health risk. International Agency for Research on Cancer (IARC) classified vinyl acetate as group 2B (possibly carcinogenic to humans). Among the organs targeted, the oral cavity is the most vulnerable organ affected by the carcinogenic effects of vinyl acetate. Since the origin of most of oral cancer is derived from the epithelial cells, it is important to understand the carcinogenic potential of vinyl acetate in human epithelial cells. Thus, the present study has attempted to utilize the immortalized human epithelial cell model to assess the carcinogenic potency of this chemical and to understand the underlying mechanisms.

키워드

Vinyl acetate Neoplastic transformation Human epithelial cell