다양한 NSAID가 인간 치주인대세포의 prostaglandin 합성 및 세포 형태에 미치는 효과에 대한 연구

• 영문명: EFFECTS OF VARIOUS NSAIDS ON PROSTAGLANDIN SYNTHESIS AND CELLULAR CONFIGURATION OF HUMAN PERIODONTAL LIGAMENT CELLS
• 발행기관: 대한구강악안면외과학회
• 저자명: 김혁수(Hyeok-Soo Kim) 심혜영(Hae-Young Shim) 채창훈(Chang-Hoon Chae) 장영일(Young-Il Chang) 박준우(Jun-Woo Park)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제33권 제5호, 455~463쪽, 전체 9쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2007.10.30

영문 초록

The present study was designed to evaluate effects of the commonly used NSAIDs(acetaminophen, aspirin, and ibuprofen) on human periodontal ligament cells. Human periodontal ligament cells were grown from a cell line provided by Kyungpook National University. Effects of NSAIDs on the proliferation of human periodontal ligament cells were assessed using MTT assays. And then PGE2 concentrations were determined by ELISA and the changes of cellular configuration were found by electron micrograph. The results were as follows; 1. The MTT assay demonstrated that the commonly used NSAIDs(acetaminophen, aspirin, and ibuprofen) had not significant cytotoxic effect on human periodontal ligament cells. 2. NSAIDs inhibited the PGE2 synthesis of human periodontal ligament cells compared with the control group. These inhibitory effects had no significant differences with NSAID type and concentration. 3. Electron micrographs of human periodontal ligament cells treated with NSAIDs showed more narrow and irregular shape.

키워드

NSAID Human periodontal ligament cell Prostaglandin Electron micrograph