결절성경화증에서 망막 성상세포과오종의 안저자가형광, 형광안저혈관조영 및 스펙트럼영역 빛간섭단층촬영 소견

• 영문명: Fundus Autofluorescence, Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Findings of Retinal Astrocytic Hamartomas in Tuberous Sclerosis
• 발행기관: 대한안과학회
• 저자명: 권영기(Young Ki Kwon) 강동진(Dong Jin Kang) 임종찬(Jong Chan Lim) 김종호(Jong Ho Kim) 박동호(Dong Ho Park) 신재필(Jae Pil Shin)
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume57,number1, 134~140쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2016.01.30

영문 초록

Purpose: To analyze the structural and morphological characteristics of retinal astrocytic hamartomas in tuberous sclerosis patients using fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography. Case summary: Fundus examination, fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography were performed in three patients with tuberous sclerosis and the morphological and structural characteristics of retinal astrocytic hamartomas were analyzed. In the fundus autofluorescence, type 1 retinal astrocytic hamartoma showed hypofluorescence and type 3 showed central hyperfluorescence and surrounding hypofluorescence. Spectral domain optical coherence tomography showed dome-shaped hyper-reflectivity within the nerve fiber layer and focal adhesion of the vitreous cortex in the type 1 retinal astrocytic hamartoma. No abnormalities were observed in the outer retinal layer and retinal pigment epithelium. In the type 3 retinal astrocytic hamartoma, optical coherence tomography showed disorganization of retinal tissue and posterior shadowing. Intratumoral cavitation and moth-eaten appearance caused by intratumoral calcification were observed and the vitreous cortex adhered to the top of the tumor and showed traction. Retinal arterial sheathing was observed in all cases and hyper-reflectivity of the arterial wall was noted on optical coherence tomography. Conclusions: Fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography are helpful for the classification and diagnosis of retinal astrocytic hamartomas found in tuberous sclerosis patients as well as for differentiation from other lesions.

키워드

Fluorescein angiography Fundus autofluorescence Optical coherence tomography Retinal astrocytic hamartoma Tuberous sclerosis