정상안압녹내장 환자에서 통합된 두 눈 시야의 결손 위치에 따른 삶의 질 비교

• 영문명: Quality of Life According to Location of Integrated Binocular Visual Field Defect in Normal-Tension-Glaucoma Patients
• 발행기관: 대한안과학회
• 저자명: 이동익(Dong Ik Lee) 박인기(In Ki Park) 정재훈(Jae Hoon Jeong) 전연숙(Yeoun Sook Chun)
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume57,number1, 86~97쪽, 전체 12쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2016.01.30

영문 초록

Purpose: To investigate the relationship between vision-related quality of life (QOL) and integrated binocular visual field (IVF) defect and the difference in QOL based on the location of visual field defects in Korean normal tension glaucoma (NTG) patients. Methods: Two hundred monocular visual fields from 100 patients diagnosed with normal tension glaucoma in at least one eye were integrated using the best location method, and the mean deviation (MD) of whole, superior, and inferior IVF was calculated. We analyzed the correlations between subscales of the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25) and each calculated MD using Spearman correlation. After adjusting for confounding factors of age, visual acuity of the better eye, number of medications, and education level, the impact of IVF loss on the composite score of the NEI VFQ-25 was evaluated using multivariate linear regression analysis. Results: The MDs of whole and inferior IVF were significantly associated with 7 of 12 NEI VFQ-25 subscales, and the superior IVF was associated with 3 subscales (p < 0.05). After adjusting confounding variables, the composite score of the NEI VFQ-25 showed significant correlation with whole, superior, and inferior IVF. The adjusted R2 and β coefficient of the regression line were highest in the whole IVF (Adjusted R2 = 0.451, β = 1.12), followed by the inferior and superior IVF (Adjusted R2 = 0.438, 0.395, β = 0.95, 0.85). Conclusions: The IVF of Korean NTG patients can effectively reflect patient QOL, and the inferior IVF was significantly associated with more subscales of NEI VFQ-25 than was the superior IVF. However, overall QOL of patients is thought to be determined by severity of visual field loss rather than its location.

키워드

Integrated binocular visual field Location Normal tension glaucoma Quality of life