망막혈관종성증식에 동반된 망막색소상피파열에서 항혈관내피세포성장인자 주입술의 임상결과

• 영문명: Intravitreal Anti-Vascular Endothelial Growth Factor for Retinal Pigment Epithelial Tear in Retinal Angiomatous Proliferation
• 발행기관: 대한안과학회
• 저자명: 황현지(Hyun Ji Hwang) 장영석(Young Suk Chang) 김종우(Jong Woo Kim) 이태곤(Tae Gon Lee) 김철구(Chul Gu Kim) 조성원(Sung Won Cho) 이동원(Dong Won Lee) 한정일(Jung Il Han) 김재휘(Jae Hui Kim)
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume57,number1, 71~79쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2016.01.30

영문 초록

Purpose: To evaluate the treatment outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) therapy for retinal pigment epithelial (RPE) tear in retinal angiomatous proliferation (RAP). Methods: In the present study we retrospectively analyzed the medical records of 14 patients (14 eyes) diagnosed with RPE tear secondary to RAP treated with intravitreal anti-VEGF. Best-corrected visual acuity (BCVA) when the RPE tear developed was compared with BCVA at 6 months and at the final follow-up. Results: The mean age of the study patients was 75.1 ± 7.0 years and the mean follow-up period was 23.7 ± 13.7 months. During the follow-up period, patients were treated with a mean of 2.8 ± 1.3 intravitreal anti-VEGF injections. The mean logarithm of minimal angle of resolution BCVA when the RPE tear developed, at 6 months and at the final follow-up was 1.25 ± 0.44, 1.44 ± 0.56, and 1.65 ± 0.39, respectively. The BCVA at 6 months was not different from the baseline value (p = 0.258), whereas the BCVA at the final follow-up was significantly worse than the baseline value (p = 0.002). Conclusions: The prognosis of RPE tear in RAP is poor despite anti-VEGF therapy. This result suggests further investigations regarding the prevention of RPE tear or more effective treatment method for this condition are necessary.

키워드

Age-related macular degeneration Anti-vascular endothelial growth factor Retinal angiomatous proliferation Retinal pigment epithelial tear