학술논문
페닐알킬 피페라진 유도체 합성과 α-Glucosidase 저해활성
이용수 16
- 영문명
- Synthesis and α-Glucosidase Inhibitory Activity of Phenylalkyl Piperazine Analogues
- 발행기관
- 대한약학회
- 저자명
- 장인혜(Inhye Chang) 이은영(Eunyoung Lee) 황보경(Kyoung Hwangbo) 김인규(In-Kyu Kim) 손경희(Kyung-Hee Sohn) 최란(Lan Choi) 이응석(Eung-Seok Lee) 우미희(Mi Hee Woo) 손종근(Jong-Keun Son) 나영화(Younghwa Na)
- 간행물 정보
- 『추계총회 및 학술대회』(2002년) vol.2, 446~450쪽, 전체 5쪽
- 주제분류
- 의약학 > 내과학
- 파일형태
- 발행일자
- 2002.10.30
4,000원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
As an effort to find a new scaffold for α-glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their α-glucosidase inhibitory activities. Compounds 8 (IC50=2.73±0.075 mM) possessing two 3-methoxyphenethyl group on 1,4-position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to α-glucosidase. The result indicated that proper substituents on the piperazine can engender α-glucosidase inhibitory activities on the piperazine derivatives.
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- COX-inhibitors down-regulateTCDD-induced cyp1a1 activity in C57BL/6 mouse and Hepa-I cells
- Dissolution Test for Indomethacin by the Portable Near-lnfrared(NIR) System
- Cellular Factors Involved in Methylmercury Toxicity in Yeast
- Effects of Platycodi Radix on dimethylnitrosamine-induced hepatic fibrosis in rats
- Induction of apoptosis in human promyelocytic leukaemia HL-60 cells by manassatin B involves release of cytochrome c and activation of caspases
- Synthesis and Characterization of Polyamines and Their Metal Complexes
- Pharmacokinetic and Pharmacodynamic Modeling of a Proton Pump Inhibitor
- Recent Developments in Analytical and Preparative Scale Enantioseparations
- Anti-inflammatory Effect of Hederagenin Glycoside Isolated from Lonicera japonica
- Control of Influenza: Live Vaccine Development
- Antidiabetic effect and mechanisms of SPH-1 in db/db mice
- Role and Action Mechanism of Secretory phospholipase A2 in Macrophage Activation
- Cholinergic involvement of spatial memory impairment in μ-opioid receptor knockout mice
- Chemopreventive and Chemoprotective Potential of Naturally Occurring and Synthetic Anti-inflammatory Agents
- Establishment of new cytotoxicity screening system using Caco-2 cells
- Effects of Sustained-Release Formulation of Recombinant Human Growth Hormone on Body weight, Bone growth and Organs in Hypophysectomized Rats
- Molecular interaction of Gα16 subunit G protein with chemoattractant receptors
- Comparison of CE and HPLC as analytical methods of (-)-yatein enantiomer from Cupressaceae plants
- The Effect of Chondroitin Sulfate against Oxidative Stress and Atherosclerosis in Ovariectomized Rat
- Neuroprotective Mechanisms of Atoesin against Focal Ischemic Brain Injury
- Saponins Isolated from the Leguminosae Plants
- The anti-inflammatory activity of Kalopanax pictus bark extract (IV). Antirheumatic activity of kalopanaxsaponin A methyl ester
- Induction of Apoptosis by N-phenyl-O-phenylthionocarbamate substitutes in SK-MEL-28 human skin cancer cell line
- A newly antiarrhythmic drug CW-2202 is ideal in treating atrial fibrillation
- Immune responses to synthetic peptides of RSV F protein
- Synthesis of Benzoquinoxalines
- Preparation of polymeric nanoparticles from hydrophobically modified pullulan for hydrophobic drug carrier
- Characterization of the rhGHr eleased from rhGH-loaded PLGA microspheres
- A Comparatives study for single-shot immunization of diphtheria toxoid with combined PLGA microspheres
- Transport of Organic Cations across Caco-2 Cell Monolayers
- Standardization of uniformity of dosage unit for oral dosage forms
- Solid Lipid Nanoparticles(SLN) as Controlled Release Subcutaneous Injections of Local Anesthetics
- Preparation and release characteristics of PVP-based solid dispersion capsules containing solubilizers
- DESIGN. SYNTHESIS AND IN VITRO EVALUATION OF APIO ANALOGUE OF NEPLANOCIN A
- Depth-profiling of skin in the near infrared using fiber optic probes
- Dexamethasone 21-sulfate sodium ： A potential colon-specific prodrug of dexamethasone
- Pipeline, a Primary Component of Black Pepper, inhibits Prostagladins Generation by Suppression of COX Activity on Arachidonic Acid Metabolism in LPS-Stimulated RAW264.7 Cells
- Inhibitory effect of 2-amino-3-ethoxycarbonyl-1-methyl pyrolo (3,2-b) naphtho-4,9-dione on tumor cell invasion in human fibrosarcoma cells by downregulating matrix metalloproteinase-2 and 9
- Comparisons of thermogenic activity among Ginseng Radix Alba (GRA), Ginseng Radix Rubra (GRR), and Panax Quinquefolii Radix (PQR)
- Sphingosine-1-phosphate Promotes the Survival of Mel-Ab Cells via ERK and Akt activation
- Assessment of allergenicity of genetically modified foods (GMOs)
- Induction of apoptosis in human promyeiocytic leukaemia HL-60 cells by yomogin involves release of cytochrome c and activation of caspase
- Tyrosine kinase inhibitors reverse lawsone methyl ether stimulation of renal dipeptidase release but not of alkaline phosphatase release
- Proteome Analysis of Apicidin-Treated Human Cervix Cancer Cells
- Effect of porcine testis-derived glycosaminoglycans on blood coagulation and immune responses
- Stable expression of N-terminal 3X-FLAG tagged human 5a-reductase type II in 293 cells：a new tool for protein purification & inhibitor screening
- Synthesis of 2,6-Diaromatic Substituted Pyridine Derivatives and Their Antitumor Activities
- Stability of the current biological drugs(typhoid vaccine)
- Synthesis of Selenoflavonoid and Selenoisoflavonoid
- 3,4-Diaryl-2(5H)-Furanone Derivatives: Synthesis, Cytotoxicity, and Antitumor Activity
- Antioxidant compounds from the twig of the Morus alba L.
- Phenolic Compounds from Barks of Pinus densiflora siebold et Zuccarini and Their NO Production Inhibitory Activities
- Butyrylcholineesterase(BChE) Inhibitors froma Brown Alga Sargassum sp.
- A Specific butyrylcholinesterase inhibitor from the fruits of Evodia officinalis
- Antioxidative activity of compounds from cuItivated Phellinus linteus
- Isolation of the ppar-y ligands from the stem of the Zanthoxylum Schinifolium and their structure activity relationships
- Simultaneous Determination of Curcumin and Glycyrrhizin Contents by High-performance Liquid Chromatography in Two Different Oriental Herbal Preparations of Kamijadowhan
- Anti-Oxidative compounds from Quercus salicina bark
- Effect of P-020701 on gastric lesion and ulcer in rats
- Triterpene Components from the Leaves of Acanthopanax sessiliflorus
- Regulation of the absorption of dietary sugar by α-glucosidase inhibitors from herbal medicines
- Xanthorrhizol inhibits pro-inflammatory mediators in mouse macrophage cells
- Transfersomes-mediated gene transfer into organs in mice by direct application on intact skin
- Effect of Polyethylenimine Type in Polylactic acid Nanoparticles/DNA Complex on the Transfection Efficiency
- Clinical Effects of Gemcitabine and 5-Fluorouracil Combination therapy and Epirubicin, Cisplatin, and 5-Fluorouracil Combination therapy for patients with Pancreatic Cancer
- Protection of Paeoniae radix from H2O2-induced oxidative DNA damage
- Effects of chitosan on the decreased renal dipeptidase release by nitric oxide from renal proximal tubules
- The 3-D QSAR study of antitumor arylsulfonylimidazolidinone derivatives by CoMFA and COMSIA
- In vitro Antitumor Activity and Nephrotoxicity of Pt(ll) Complexes Containing Diaminocyclohexane
- Terpenoids from Artemisia rubripes Nakai
- Studies on the constituents of the aerial part of Gastrodia elata Blume
- Development of Immunostrip for DDT Detection
- Analysis of the chemical burn-inducing components from the extraction of herb drug-mixed-medicine
- Mucoadhesive Drug Carrier Using Poly(acrylic acid)/poly(vinyl alcohol) Interpolymer Complexes by Template Polymerization
- Pharmacokinetics of DA-3021 (mono-PEGylated recombinant human interferon α-2a) after Subcutaneous Administrations to Experimental Animals
- Genetic Suppressor Elements that Halt the Proliferation of Breast Carcinoma Cells.
- In Vivo Roles of Lysophospholipid Receptors Revealed by Gene Targeting Studies in Mice
- In vitro Antiinflammatory Activity of 23-Hydroxyursolic Acid Isolated from Cussonia bancoensis in Murine Macrophage RAW 264.7 Cells
- Induction of apoptosis by benz[f]indole-4.9-dione analog in human lung cancer cells through p53-depencient mechanism
- Evaluation of electroretinogram and retinal histopathology in rabbits administered DA-8159, a selective PDE 5 inhibitor
- Changes of serum immunogiobulin in the subacute oral administration of bisphenol A
- Comparative Stuies on the Detection of Drug-Toxic Substances in the Formalin Fixed and Unfixed Tissue Specimens
- Chronic exposure of nicotine modulate the expressions of cerebellar glial glutamate transporters in rats
- In utero exposure to 2.3'.4.4', 5-Pentachlorobiphenyl (PCS 118) alters postnatal reproductive development in female rat
- Antiplatelet Activity of NQ12 May Be Mediated by Inhibition of Cyclooxygenase and Generation of 12-HETE
- Allicin reduces expression of Intercellular Adhesion Molecule-1 (ICAM-1) in gamma-irradiated endothelial cells : Involvement of p38 MAP kinase signalling pathway
- Diasteroselective synthesis of long chained keto amino acids derivatives
- Anti-angiogenic activity of conjugated linoleic acid on the basic fibroblast growth factor-induced angiogenesis
- The ermk leader peptide alterations leading to differential efficiency of induction by erythromycin
- A new 4-hydroxy-dodec-2E-enedioic acid from the stem bark of Albizzia julibrissin
- Discrimination of Cnidium Rhizome using PCR-mediated RFLP
- Chiral Synthesis of Costunolide
- Studies on the Analysis of Anti-impotent Drugs
- Determination of triflusal in human plasma by high performance liquid chromatography with automated column switching system
- Determination of Histamine in a Pharmaceutical Preparation after Clean-Up by Solid–Phase Extraction
- Proficiency Test for Pharmaceutical Companies in Analyzing Drug Products (Ⅱ) - Analysis of Variance of Factors Influencing Test Results
- Adenosine inhibits the death in immunostimulated murine astrocytes deprived of glucose
- A Collaborative Study to Establish a Korea National Biological Standard for Antithrombin Concentrate
- DA-7911, rhenium-188(Re188) tin colloid, as a strong candidate agent for radiation synovectomy
- Comparison of CYP 3A4 metabolism between DA-8159 and Sildenafil in vitro and in vivo
- Mechanism of immunostimulating action of polysaccharide isolated from Platycodon grandiflorum in RAW 264.7 macrophages
- Pharmacology of novel vanilloid receptor antagonists
- Metallothionein gene expression in different tissues of Crucian carp (Carassius auratus) exposed to cadmium chloride
- Quercetin analogs extracted from Lidera erythrocarpa protects heart-derived H9c2 cells from oxidative stress-induced death
- The modulating activity of Ginsan on radiation-induced disturbance of antioxidant defense systems
- Anti-/pro-apoptotic regulatory potentials of LPS/IFN-y in the mulnutrition induced macrophage
- Additional Sesquiterpene Lactones from Ixeris sonchifolia
- Five compounds from leaves of Hovenia dulcis T
- Analysis of DA-6034, a New Flavonoid Derivative in Biological Fluids by Fluorescence Detector
- Narrowbore high-performance liquid chromatographic method for the determination of cetirizine in plasma using column switching
- Enantiomeric Profiling Analysis of NSAIDs by Capillary Electrophoresis Using TM β-Cyclodextrin as the Chiral Selector
- Chiral separation of β-blockers after derivatization with a new chiral derivatization agent, GATC and Comparison with GITC on derivatizing conditions and chromatographic parameters
- Immunomodulatory activity of acharan suIfate isolated from Achatina fulica
- Action of lysophosphatidylcholine in U937 human monocytes
- The anti-inflammatory activity of Kalopanax pictus bark extract (V). Effects of saponins from KP on NF-κB and elastase activities
- The Screening of Hepatic Functional Improvement, Liver Protection and Antifibrotic Effect from Dried Extracts of Concha Cipangopaludinae
- Inhibitory effects of a new iridoids, patridoid I and II on TNF, iNOS and COX-2 expression in cultured murine macrophages
- Intranasal Vaccination with Conjugate Vaccines Protects Against Invasive Disease Caused by Encapsulated Bacteria entering the Body Via the Respiratory Mucosa.
- GREEN TEA EXTRACT INHIBITS CATECHOLAMINE RELEASE IN THE PERFUSED RAT ADRENAL GLAND
- Solution-Phase Synthesis of a Library of Biaryl Amides Using Girard's reagent T as an Acid Chloride Scavenger
- Pharmacokinetic Scaling of SJ-8029, a Novel Anticancer Agent Possessing Microtubule and Topoisomerase Inhibiting Activities, by Species-lnvariarit Time Methods
- The Production of IFN-y by 3LL/TNF-α-Activated Macrophages Requires p38. JAK-2 Signalling and is Enhanced by New Protein Synthesis
- A New Synthesis of Hydantoin derivatives by the Reaction of Unnatural Amino acids with Potassium Isocyanate
- Anticancer and Antiviral Effect of Some Triterpenes Isolated from the Natural Sources
- Rapid Analysis of Metabolic Stability and Structure of Metabolites in New Drug Development
- The Applications and The evaluation Methods for the Brain Uptake and Delivery of Candidates of New Drug
- Phenolic Compounds from Barks of Ulmus macrocarpa and Their Antioxidative Activities
- High Throughput Screening System for Kinetics of Brain Influx
- Targeting of Large-molecule Radiopharmaceuticals across the Blood-brain Barrier Using Endogenous TVansport Systems
- Cell signaling and therapeutic drug target for the treatment of liver cirrhosis
- Proteomics in Drug Discovery
- Hepatobiliary Transport: Mechanisms, QSAR and Regulation
- A new mechanism for unsaturated fatty acid biosynthesis in Streptococcus pneumoniae
- Concentrations of Dextromethorphan in Urine and Blood of Two Crime Suspects
- Metabolic Activation of Marijuana Constituents, Caimabinoids, in Relation to Their Toxicity for Human and Its Oxidation Mechanism
- Immunosuppressive activity of Allergina
- Effects of ascorbic acid according to administration doses on radiation induced DNA damage in mouse splenic and blood lymphocytes
- Comparison of Ginsenosides Composition in Various Panax Ginseng Roots Cultivated in Different Places and Years
- Comparative Studies of Molecular Mechanisms of Dopamine D2 and D3 Receptors for the Activation of Extracellular Signal Regulated Kinase 1/2 in HEK-293 cells
- Environmentally benign, Background-free protein staining in SDS-polyacrylamide gels using an counter ion-dye complex solution
- Epigallocatechin Gallate inhibits Prostagladins Generation by Suppression of cPLA2 Activity on Arachidonic Acid Metabolism in LPS-Stimulated RAW264.7 Cells
- Inhibitory Effects of Natural Plant extracts on ICAM-1/LFA-1Mediated Adhesion of HL-60 Cells
- Inhibition of C2-ceramide induced contraction in cat esophageal smooth muscle cell by newly synthesized Ceramide analogues
- Relationship Between Flavonoid Structure and Inhibition of Farnesyl Protein Transferase
- Culture of rabbit chondrocytes on the HA-agarose scaffold for artificial cartilage
- Levels of organochlorine pesticides and PCB congeners in Korean human tissues
- Application of in situ gelling mucoadhesive delivery system for plasmid DNA as a macromolecule
- Neuroprotective Effects of Treatment with Aloesin in Rat Model of Permanent Focal Cerebral Ischemia
- Modulation of carcinogen-activating enzymes by synthetic trans-stilbene analogs
- Differential Protein and Gene Expression after Adenovirus-Mediated p16 Gene Transfer in Human Non-Small Cell Lung Cancer Cells
- Orphan G Protein-coupled Receptors in Post-Genome Era
- Site-specific PEGylation of Peptide Drugs
- Mechanistic Pharmacokinetic/pharmacodynamic Modeling in Isolated Perfused Organs and at the Whole-Body Level
- Synthetic study of costunolide
- Inhibitory effects of resveratrol analogs on lipopolysaccharide-induced cyclooxygenase-2 activity in RAW 264.7 cells
- Revers phase HPLC Separation of D-Amygdalin and Neoamygdalin and Optimum Conditions for Inhibition of Racemization of Amygdalin
- High-Throughput Screening for Novel Inhibitors of Protein-Tyrosine Phosphatase-1B
- Arachidonic Acid Liberated through Activation of iPLA₂Mediates the Production of Reactive Oxygen Species and Apoptosis Induced by N-Ethylmaleimide in HepG2 Human Hepatoma Cellls
- PLATYCODIN D, NOT D3, CAUSES VASODILATATION IN THE RAT
- Report on the trends of the Drug Abuse and the Mortalities related to Intoxication of Drug-Toxic Substances in the Central Area of Korea in 2001
- Studies on the protective effect of Cheju and Brazil pectin on the male reproductive system damaged by 2.3.7.8-tetrachlorodibenzo-P-dioxin
- Down-regulation of inducible nitric oxide synthase and tumor necrosis factor-a expression by Bisphenol A via nuclear factor-kB inactivation in macrophages
- Estrogenic Activities of Pyrethroid Compounds in MCF-7 BUS cells
- Effect of oral administration of Ginsenoside-Rb2 on rotavirus infection
- non-viral gene delivery mediated by chitosan and PEI ： developement of a gene carrier with serum stability and reduced cytotoxicity
- Ceramide analogs inhibit inducible nitric oxide synthase expression and nitric oxide production in interferon-gamma and lipopolysaccharide-stimulated RAW 264.7 macrophages
- Isolation, structure, and NF-kB modulatory activity of Harziarum A and B: trichothecene from fungi (B000527)
- GDNF Enhances Hs683 Human Glioma Cell Migration：Possible Involvement of MAPKs
- Inflammation, Injury and Transcription Factors in Chronic Lung Diseases: Therapeutic Targets
- Diastereoselective Synthesis of (+)-Frontalin
- Analysis of Branched PEG-Conjugated Interferon Alpha by Capillary Electrophoresis and MALDI-TOF Mass Spectrometry
- Comparison of isoBOC derivatives, TBDMS derivatives, with US EPA Method in the sensitivity of Alkylphenols, Chlorophenols, and Bisphenol A potential field-screening applications of GC/MS-SIM
- Phosphatidylinositol 3-Kinase Regulates Nuclear Translocation of NF-E2-Related Factor 2 through Actin Rearrangement in Response to Oxidative Stress
- Selective B cell activation by polysaccharide isolated from the root of Acanthopanax koreanum
- Inhibitory Effect of Luteolin on TNF-α-Stimulated IL-8 Secretion from Intestinal Epithelial Cells
- Chemopreventive effect of Ginkgo biloba extract on breast cancer : Regulation of estrogen level
- An investigation of the effect of epigallocathechin-3-gallate on the renal dipeptidase release
- Role of phospholipid metabolism in Methylmercury-induced Cytotoxicity
- Toxicological Evaluation of Oriental Herbal Medicine Kamijadowhan Preparations
- The effect of some natural products on mouse melanoma cells in vitro
- An In Vitro Bioassay for Nerve Growth Factor
- Studies on standardization and characterization of recombinant interferon alfa
- Decusinol angelate inhibits UVB-induced MMP-1 induction via Mitogen-activated Protein Kinase Pathway in human skin fibroblasts
- Cleavage of Benzyl and p-Methoxybenzyl Ethers Using Chlorosulfonyl Isocyanate Reaction
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- Optimization of a fiber optic probe for non-invasive blood glucose monitoring
- Drug Use Evaluation of Hypoglycemic Agents in Type 2 Diabetes
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- Development of a new Cox-2 inhibitor as an anticancer agent
- Pharmacokinetic and Pharmacodynamic Modeling of Levodopa in Parkinson Disease
- Pharmacokinetic and Pharmacodynamic Characteristics of Cyclosporin A in Rats and Rabbits
- Effect of Drugs on the Cardiac Transport, Metabolism and Action of Idarubicin: Pharmacokinetic and Pharmacodynamic Modeling
- 4-Hydroxy nonenal (HNE) Induces Apoptosis and Cell Cycle Arrest in Bovine Aortic Endothelial Cells
- Effects of cationic polyamines under 10 kD range of molecular weight on basic and induced mucin release from airway goblet cells
- Changes of serum immunoglobulin in the subacute oral administration of Mancozeb
- Effects of Protein Kinase Inhibitors on Histamine Release and ROS Generation in RBL 2H3 Cells
- Design and Synthesis of Benzoquinoxalinediones
- Ginsenosides Content of The Manufactured Ginseng Radices Extracts
- Algorithm for finding the best regression models using NIR spectra
- Does Agitation Condition Affect the Correlation Between in vitro Permeability of Xenobiotics across Caco-2 Cells and in vivo Bioavailability of the Compounds?
- Hypoglycemic Effect of Ginseng Radix alba(GRA) in Multiple Low Dose Streptozotocin-induced Diabetic Rats
- Studies on Anti-inflammatory effect of Clerodendron trichotomum Thunberg Leaves
- Activation of mouse macrophage cell line by aloe gel components：The carbohydrate fraction from Aloe vera gel
- Synthetic Approaches to Benzophenanthridines
- Regio- & Stereoselective Synthetic Method for Polyhydroxyamines using Chlorosulfonyl Isocyanate
- A novel triterpene saponin from the roots of Platycodon grandoflorum
- On the Contents of Alkaloids in the Cho O by Processing Methods
- lontophreotic delivery of vitamine-C-2-phosphate
- Total synthesis of deoxy-azasugars
- Antitum or activity of oxaliplatin, 5-FU and paclitaxel given alone and in combination with ZD1839 in human gastric carcinoma cells in vitro
- The pharmacological effect of the methanol extracts from Acanthopanax senticosus after immobilized and chronic swimming stresses in rats
- Roles and signaling pathway of M2 pyruvate kinase in RBL-2H3 cells
- Histamine Releasing Factor (HRF) Evokes [3H]Dopamine Release by a Ca²+ -independent Pathway in Pheochromocytoma Cells
- Heterotrimeric G protein y12 Subunit is Region-Specifically Expressed in Rat Brain
- Peroxynitrite Scavenging Activity of Active Constituents from Scutellaria baicalensis
- Flexible docking of novel antitumor agents into human topoisomerase l-DNA complex with FlexiDock
- Purification and Characterization of Dermatan Sulfate from Eel Skin, Anguilla japonica
- Alkaline protease of Actinomycetes CS0703：Isolation, production and characterization
- (-)-β-Narcotine：A Facile Synthesis and the Degradation with Ethyl Chloroformate
- Simultaneous quantitation of enalapril and enalaprilat in human plasma by high-throughput solid phase extraction and liquid chromatography/tandem mass spectrometry
- The Effect of Nimodipine on the Pharmacokinetics of Cyclosporine in Rabbits
- Growth inhibition and cell cycle phase-specific apoptosis induced by celecoxib in human NSCLC cells in vitro
- Incidence level ot abnormality in creatine phosphokinase by statin
- Determination of Optical Purity of a-Arylmethylpropionic acds by Normal Phase Liquid Chromatography
- Hydrogen Peroxide Activates ERK in Cultured Feline Ileal Smooth Muscle Cells
- The influence of extremely low frequency magnetic field on cardiovascular response
- Synthesis and Antifungal Activities of 2,5-Disubstituted-6-Arylamino-4,7-benzimidazolediones
- SYNTHESIS OF [1-FLUORO-2,2-BIS-(HYDROXYMETHYL) CYCLOPROPYLMETHYL] PURINESAS ANTIVIRAL AGENTS
- Antigastritic and anti-ulcerative constituent from Panax ginseng head and its pharmacological activity
- In vitro antioxidant triterpenoids from Prunus serrulata var. spontanea
- New Analytical Method of Cyclosporine A in Human Serum by High-performance Liquid Chromatography/Diode Array Detector and Its Application to Pharmacokinetics of Cyclosporine A in Human Volunteers
- Biological Activities and Constituents of the Semen of Rumex crispus
- The Differential Roles of Glutamine Synthetase in Methylmercury Neurotoxicity
- The toxicity of Aceporol 460 as a novel high loading capacity solubilizer of paclitaxel
- Role of Kupffer Cells in Alteration of Vasoregulatory Gene Expression in Hepatic Ischemia/Reperfusion
- The effects of extremely low frequency magnetic field on bicuculline, picrotoxin, NMDA-induced seizures in mice
- Histoculture drug response assay in Human colorectal cancer patients of novel Pt(Ⅳ) complex, K101 and nephrotoxicity test in ICR mice renal proximal tubular cells
- Sphingosine-1-Phosphate Decreases Melanin Synthesis via Sustained ERK Activation and Subsequent MITF Degradation
- Corticosteroids and Proximal Femur Fracture in Elderly W omen ： the KEPEC Study
- New Formulation of Vitamin A Transdermal Therapeutic System
- GENISTEIN INHIBITS NF-κB-DEPENDENT COX -2 INDUCTION IN HUMAN BREAST EPITHELIAL CELLS BY MODULATING THE ACTIVATION OF TATA-BINDING PROTEIN
- Newly Designed Six-membered Azasugar-Containing Phosphorothioate Oligonucleotide as a Potent AIDS Therapeutic Drug
- Simultaneous determination of corticosteroids in a herbal medicinal preparation by GC-MS
- Surfactant-free microspheres of poly(£-caprolactone)/poly(ethylene glycol)/poly(£-caprolactone) tribtock copolymers as a novel protein carriers
- Isolation and Structure Determination of Cytotoxic Compounds with Topoisomerse I and II Inhibitory Activity from the spikes of Prunella vulgaris var. lilacina
- Temperature Regulates Melanin Synthesis in Mel-Ab Cells
- Bioactive Fabaceous Saponins and Structure-Activity Relationship
- Development of Mechanism-based Irreversible Inhibitors of S-Adenosylhomocysteine Hydrolase as Borad-spectrum Antiviral Agents
- Three-dimensional Pharmacophore Mapping of a Series of Isoxazolylpiperazine Inhibitors Selectively acting on the Dopamine D4 Receptor
- Signaling and Proteomics in Methylmercury Exposure
- Biological Activity of Lanostane-type Triterpenes from Ganoderma lucidum
- Selectivity of the optical isomers of KR30031 on MDR reversal activity and cardiotoxicity
- The effects of estradiol and its metabolites on the regulation of CYP1A1 expression
- Immuno-modulator effect of Cefodizime in lL-6
- Proliferation of Hematopoietic Cells by Pheliinus linteus polysaccharide
- Involvement of Akt in naphthoquinone analog-induced apoptosis in HL-60 cells
- Tetrandrine induces mitochondria-dependent apoptosis in HepG2 cells
- Role of Metabolic Activation by Cytochrome P450s in Chemical-induced Immunosuppression
- IL-1β Expression of Cefodizime on Dendritic cell and Macrophage
- Alteration of Hepatic Drug Metabolizing Function after Traumatic Injury
- Flexible docking of stereoisomers of allyl substituted penam sulfones into metallo-β-lactamase with QXP
- Administration of BCG-CWS in oil-in-water emulsion inhibits tumor growth and metastasis
- Risk assessment of endocrine disruptors in cosmetics
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