Bioactive Fabaceous Saponins and Structure-Activity Relationship

• 발행기관: 대한약학회
• 저자명: Junei Kinio
• 간행물 정보: 『추계총회 및 학술대회』(2002년) vol.2, 143~146쪽, 전체 3쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2002.10.30

영문 초록

Saponins are glycosidic compounds present in many edible and inedible plants. Structurally, they are composed of a lipid-soluble aglycone consisting of either a sterol or, more commonly, a triterpcnoid and water-soluble sugar residues differing in type and amount of sugars [1]. Because of their amphiphilic nature, they are highly surface-active. Their biological activity is closely related to the chemical structures that determine the polarity, hydrophobicity and acidity of compounds [1]. A recent review by Safayhi and Sailer shows that pentacyclic triterpenes, like as oleanane skeleton, might be a rich natural source of lead compounds for anti-inflammatory drug development [2]. Some oleanane-type triterpene saponins are known to exhibit anti-hepatic (hepatoprotective) activity. Among them, glycyrrhizin and saikosaponins [1] are the most well-known. Oleanene-glucuronide (OG) would be defined as an olean-12-ene type triterpene with a C-17 methyl group and a glucuronic acid moiety linked at the C-3 of the triterpene. Soyasaponin I (1) is a representative OG, and glycyrrhizin also belongs to the OG species. It has been revealed that OGs are widely distributed in the fabaceous (Faboideae in Leguminosae) plants and show several biological activities. For example, anti-hepatitis, anti­ hypercholesteremia, anti-urolithiasis, anti-inflammatory, and anti-nephritic activities were confirmed in experimental in vivo models. And, antiviral, anti-complementary, and calcium-dependent potassium channel-opening activitieswere examined using in vitro models [1]. In view of the fact that leguminous plants are widely distributed and used as foodstuff and folk medicines, we have focused on these plants and have been trying to develop natural medicines after proving the effectiveness of these crude drugs and to find the lead compounds among these natural sources. Herein, we describe the structures of OGs a n d some of their biological activities, probing into the structure-activity relationships.

목차

1. Isolation and Structures of OGs

2. Hepatoprotective Effects and Structure-Activity Relationships [3]

3. Anticomplementary Activity and Structure-Activity Relationships [5]