학술논문
Proteomics in Drug Discovery
이용수 0
- 영문명
- 발행기관
- 대한약학회
- 저자명
- W. Rodney M athews
- 간행물 정보
- 『추계총회 및 학술대회』(2002년) vol.2, 73~73쪽, 전체 0쪽
- 주제분류
- 의약학 > 내과학
- 파일형태
- 발행일자
- 2002.10.30
무료
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
The study of the protein complement of the genome, or proteome, represents an important new avenue for drug discovery. Proteomics research aims to quantify and characterize all of the expressed proteins in a biological system, and to determine the effect of various perturbations of the system on the expressed proteins. The resulting protein expression data can then used to help discover and characterize new drug targets, evaluate the mechanism of action of lead compounds, and investigate potential toxicity of novel therapeutic agents. A critical aspect of proteomics is protein identification. Mass spectrometry enables rapid identification and characterization of expressed proteins and bridges the gap between genome and proteome. A flexible, high performance protein identification system based on commercially available instrumentation has been assembled and implemented. The performance of the system, including validation with protein standards and its application to real world problems in drug discovery will be described.
목차
키워드
해당간행물 수록 논문
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- Accurate Chiral Discrimination of Acidic- and Amino acidic-Chiral Drugs by Indirect GC and Direct CE Enantiomeric Separation Methods
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- Efficient Solid Phase Library Synthesis of 7-Alkoxy-1,3,4,5-tetrahydro-benzo [e][1,4] diazepin-2-one
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- Neuroprotective effect of wogonin in a rodent model of permanent focal cerebral ischemia
- Determination of the water content in Citrus leaves by portable near in frared (NIR) system
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- The Effects of Oral Administrations of Panax ginseng and P. quinquefolium on Hemodynamics and Body Temperature in Healthy Young Men : Results of Single Blind Test
- A convenient synthesis of 2' or 3'-amino-2'(or 3')-deoxyadenosine and 5'-chloro-2' (or 3')-amino-deoxyadenosine analogues
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- Stereoselective synthesis of novel 4'α-C-methyl branched novel carbocyclic nucleosides
- Biochemical analysis of a high-molecular-weight protease from Streptomyces tendae JC412
- Asymmetric Synthesis of 12(S)-HETE
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- Further Studies on Anti-angiogenic Activity of Gardenia jasminoides Fruit
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- Cloning, Sequencing and Characterization of the Novel Penicillin G Acylase Gene from the Soil-isolated Ledercia adecarboxylata
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- Anti-inflammatory, analgesic, and hypouricemic effect of Actinidia polygama(AP)
- Synthesis and Antiinflammatory Activity of 1,5- and 4,5-Disubstituted Imidazoles
- Purification and Chracterization of fibrinolytic enzymes from Vegetable warms
- THE RELATIONSHIP OF INTESTINAL ABSORPTION CLEARANCE AND PARTITION COEFFICIENT OF NINE BETA-BLOCKERS IN RATS
- Pharmacokinetics of New Solubilizer in Intravenous Micelle Formulation of Paclitaxel in Mice
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- Antimicrobial effects of ocotillone isolated from the stem bark of Ailanthus altisshima
- Synergistic effect of a mixed herbal extract on bone loss in ovariectomized (OVX) rats
- Structural Requirement of Isoflavonones for the Inhibitory Activity of Interleukin-5
- Chemiluminogenic imaging for highly sensitive detection of DNA
- Synthesis of 3-arylisoquinolinamines and 3D-Quantitative Structure Activity Relationships Study
- Enhanced p53 Gene Transfer to Human Ovarian Cancer Cells using Cationic Nonviral Vector, DDC
- Isolation of inhibitors of NF-κB activation by UV stimuli in transfectant HaCaT cells from Acanthopanacis sessilifflorum
- Tyrosinase and melanin biosynthesis inhibitory activities of crude drugs
- Transforming Growth Factor-β(TGF-β) Induces Invasion and Migration of Ras-Transformed MCF10A Human Breast Epithelial Cells
- Study on antifungal activity of herb oils against Trichophyton spp
- HPLC Determination of Loratadine in Human Plasma with UV Detection and Pharmacokinetics of Loratadine Following Oral Administration of Tablet Formulation in Human
- In vitro and in vivo transfection efficiency of a cationic lipid containing sodium cholate
- Design, Synthesis and Antitumor Evaluation of Terpyridine Derivatives Containing Pyridines at 4'-Position
- Apicidin Induction of cyclin E might be mediated by Sp1 Transcription Factor
- New tsaokoin isomer with antifungal activity from the plant Amomum tsao-ko
- Cytotoxicity and Antimutagenic Activity of the Thorns of Gleditsia sinensis Lam
- Cytotoxic Constituents from Amanita pantherina(DC.ex Fr.) Krombh
- The Versatile Conversion of Acyclic Amides to a-Alkylated Amines
- Alternation of Adhesion Molecules during Aging and Modulation by Calorie Restriction
- Molecular Dynamics Simulation of Enantioselectivity in Metoprolol in complex
- Computer-based screening for novel inhibitors of human topoisomerase I with FlexiDock docking protocol
- In vitro Antiinflammatory Activity of the Essential oil Extracted from Chrysanthemum sibiricum in Murine Macrophage RAW 264.7 Cells
- EFFECTS OF ISOTHIAZOLE AND ISOXAZOLE DERIVATIVES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS
- Study on the inhibition of Whole Blood Plateiet-Aggregation and antioxidative effects from Rhus verniciflua Stokes
- Structure-Activity Relationship Study of Asiatic Acid Derivatives for New Wound Healing Agent
- Role of Kupffer Cells in Hepatic Drug Metabolizing Dysfunction during Polymicrobial Sepsis
- Regioselective Substitution of 6,7-Dichloroquinoline-5,8-dione: Synthesis, Cytotoxicity, and X-ray crystal stucture of 4a, 10,11-Triazabenzo[3,2-a]fluorene-5,6-diones
- Assay of Human Chorionic Gonadotropin in Urine of Athletes and Evaluation of Assay Kit Performance
- POPULATION PHARMACOKINETICS OF TERBINAFINE IN HEALTHY MALE KOREAN SUBJECTS USING NONMEM
- Pharmacodynamics of anticancer activity of tirapazamine and paclitaxel against human NSCLC
- Synthesis of 14C-Radio Isotope Labeled Quinolone Intermediates
- Curcumin Inhibits Phorbol Ester-induced Expression of Cyclooxygenase-2 In Suppression of Extracelluar Signal-regulated Kinase(ERK)1/2 and NF-κB in Mouse Skin
- Current Status of Medication Counseling Service at Community and Hospital Pharmacies in Korea Based on Nation-wide Survey Research in 2002
- Developement of Quantitative Extraction Method of Amygdalin without Enzymatic Hydrolysis from Tonin(Persicae Semen) by High Performance Liquid Chromatography
- Synthesis and Biological Evaluation of Pyrimidine Nucleosides Fused with 3',4'-Tetrahydrofuran Ring
- Two new acylated neoline derivatives from Aconiti Tuber
- DESIGN AND SYNTHESIS OF A3 ADENOSINE RECEPTOR LIGANDS. 2'-FLUORO ANALOGUES OF Cl-IB-MECA
- Tissue Distribution of Novel Polymeric Micellar Paclitaxel in Mice
- Ligand-Based Virtual Screening for inhibitors of PTP-1B with Antihyperglycemic properties
- Anti-oxidant activities of the extracts from the herbs of Artemisia apiacea
- Simultaneous determination of seven major human cytochrome P450 activities using LC/MS/MS
- Screening and Confirmation of Designer Drugs and Anorectics in Urines using Immunoassay and GC/MS
- Attenuation of monocrotaline-induced pulmonary hypertension with DA-8159, a potent PDE 5 inhibitor
- Tyrosinase Inhibiting and DPPH Radical Scavenging Activities of Rosmarinic Acid and Its Methyl ester from Salvia miltiorrhiza
- Protective effect of KR-32000 against hypoxia-and oxidative stress-induced cardiac cell death
- β-ketoacyl-acyl carrier protein synthases for fatty acid biosynthesis in bacteria
- Inhibitory effects of new quinone compounds on eNOS activity in rat aorta and nNOS activity in rat brain
- The Lipidperoxidative effect of Houttuynia cordata Thunb & Saururus chinensis
- Effects of aqueous extract isolated from Platycodon grandiflorum against oxidative stress in rat primary hepatocytes
- TOLERANCE AND PHARMACOKINETICS OF SINGLE-DOSE DA-8159, A SELECTIVE PDE5 INHIBITOR. IN HEALTHY MALES
- Neuroprotective effects of baicalein, baicalin, and wogonin in primary cuItured rat cortical cells
- Revisit to Unfulfilled Premise of Arylsulfonylimidazolidinones as Anticancer Agent
- Anti-asthmatic agents of Gastrodia elata Rhizoma MeOH extracts
- Simultaneous Determination of Underivatized Diazepam and Nordiazepam in Plasma Using Gas Chromatography/Mass Spectrometry
- Induction of penile erection in spinal cord-injured rabbits by administration of DA-8159, a new selective PDE 5 inhibitor
- Genetic Effects on Exposure to Polycydic Aromatic Hydrocarbons in a Korean Population
- Qualification of various polymorphs by near-infrared(NIR) spectrophotometer
- IL-12 Expression by Cefodizime As an Immuno-modulator
- Assay Validation of Lansoprazole in Human Plasma
- Sexual Dimorphic Effects of Terbufos on Acetylcholinesterase and Lethality
- Synthesis of Azaisoflavones and Evaluation of Their Inhibitory Effects on lL–5
- 5~Arylidene-2(5H)-furanone Derivatives: Synthesis and Structure-Activity Relationship toward Cytotoxicity
- Erk activation mediates mediates lipopolysaccharide-induced induction of matrix metalloprotease-9 from rat primary astrocytes
- Synthesis of Novel 3-Aminohydantoinyl-1,2-benzothiazine Derivatives for the COX-2 inhibitors
- Identification of a 68kDa cytosolic, neutral and Mg2+-independent Sphingomyelinase by MALDI-TOF Analysis
- Biomolecular Mechanism of Cadmium Toxicity
- ROLES OF PGE₂AND 15-DEOXY-Δ¹²,¹⁴PROSTAGLANDIN J₂IN ET-18-O-CH₃-INDUCED INFLAMMATORY CELL DEATH
- Antidiabetic effect and mechanisms of SPH-2 in db/db mice
- Development of a high-performance liquid chromatographic method for the determintion of levosulpiride in plasma
- Tacrolimus and cyclosporine A inhibit both class I-restricted presentation pathway and classⅡ-restricted presentation pathway of exogenous antigen
- Submicrosecond dynamics of nucleic acids studied with a long-lifetime metal-ligand complex
- Microglial activation and tyrosine hydroxylase immunoreactivity in the substantia nigral region following transient focal ischemia in rats
- Proficiency Test for Pharmaceutical Companies in Analyzing Drug Products (I) - Comparison of Criteria for Satisfactory Test Results
- Aluminium increase Iron uptake into Glial cells
- Three Cytotoxic compounds isolated from the seeds of Pharbitis nil
- Effects of pyrethroid compounds on alkaline phosphatase activity in estrogen receptor positive human breast cancer cells
- Isolation of α-Glucosidase Inhibitor Producing Soil Microorganism and Inhibitory Effects of Microbial Metabolites on α-Glucosidase
- 23-hydroxyursolic acid Induces Apoptosis of human leukemia HL-60 cells
- Nonviral Vector for Efficient Gene Transfer to Human Ovarian Adenocarcinoma Cells
- The properties of ginseng saponins metabolizing intestinal bacteria
- The first synthesis of 4'α-C aryl branched carbocyclic nucleosides
- Osteoanagenesis Effect Of Hwang-Chil. a natural resources of Korea
- Decursin derivative-004 protect renal cell damage via p38 MARK inhibition
- Proteomic Analysis of Gastric Cancer Patient Sera
- CoMFA of 1-phenyl-2-substituted thioureas for their cytotoxicity
- ZR-75-1human breast cancer cells to study the mechanism of action of PAHs
- Production, purification and characterization of extracellular protease from Streptomyces scabiei subsp. chosunensis M0137
- Vitamin K Antagonist, NQ12 Inhibits PDGF-BB-lnduced MAP Kinases Activation in Rat Aortic Vascular Smooth Muscle Cells
- A new strategy for high productivity of Erythropoietin in CHO cell by introducing urea cycle enzymes
- In vitro mutagenicity and genotoxicity study of PAHs and nitro-PAHs using the bacterial revertant (Ames) test and alkaline single cell gel electrophorosis (Comet) assay
- Effect of the Extract of Cultured Ginseng Roots on Hyperlipidemia in Rats
- Studies on the Analysis of Anti-impotent Drugs (Ⅱ) - Rapid analysis of Sildenafil and modified Sildenafils using HPTLC
- Lead Discovery and Optimization towards FXR Specific Compounds
- Binding modes of artemisinin to malarial TCTP demonstrated by computer modeling
- Anti-proliferative Effects of Ixeris sonchifolia H. Extracts on Human Hepatocellar Carcinoma Cells
- Immunomodulatory activity of a polysaccharide isolated from cell culture of Acantopanax senticosus
- Analysis of bufotoxins in toad venom and toad eggs
- Synthesis and Evaluation of Biological activities of New Imine Derivatives of Apicidin
- Protective effect of metabolized Yangguksanwha-tang on Hypoxia/Reperfusion induced-PC12 cell damage
- Chiral Separation of Aromatic Acids by Capillary Electrophoresis Using HP β-Cyclodextrin as the Chiral Selector
- Antihyperlipidemic effect of Alpinia oficinarum
- Pathogenic and immunological properties of alcohol dehydrogenase in Streptococcus pneumoniae
- Simultaneous determination of thirteen cosmetic preservatives in skin creams by HPLC-PDA method
- Chiral discrimination studies of (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid by NMR spectroscopy
- Total synthesis of Antofine by using Intramolecular 1,3-dipolar cycloaddition of Azidealkene
- Mn²+ dependent ClpL ATPase in Streptococcus pneumoniae
- IN VIVO METABOLISM OF 2-METHYLAMINOETHYL-4,4'-DlMETHOXY-5,6,5',6'-DIMETHYLENEDIOXYBIPHENYL-2-CARBOXY-2-CARBOXYLATE (DDB-S) BY LC/ESI TANDEM MASS SPECTROMETRY
- Inhibitory Effects of 1,3-Selenazol-4-one Derivatives on Mushroom Tyrosinase
- Quantitative determination of pseudoephedrine in human plasma by reversed-phase liquid chromatography-electrospray ionization mass spectrometry
- Potentiometric Characteristics of Metal(Ⅱ)-Triethylene tetramine-Acidic Drug Membrane Electrodes
- Development of economic preparative method of (S)-(+)-enantiomer of arylpropionic acids
- Safety pharmacology study of AS2-006A, a new wound healing drug
- Transcriptional Responses of Respiratory Epithelial Cells to Nontypable H. influenzae Infection: Identification of Differentially Regulated Genes by Microarray Analysis of Human cDNA
- Development of rapid, sensitive and reproducible paraquat analysis method in the postmortem specimens
- Development of a New Gut-targeted Oral l^phoid Vaccine Ty21a
- HPLC Resolution of Enantiomers Using Polysaccharide Derivatives as Chiral Stationay Phases
- Pharmacological actions of H2O and MeOH extract of Opuntia ficus-indica Semen
- The Immunogenic Peptide for Thl Development and Its Adjuvant Activity
- Anti-inflammatory Action of Calorie Restriction for Life-Prolongation: A Possible Mechanism
- The Antiproliferative Effects of Bile Acids and Their Derivatives on HepG2 Human Hepatocellular Carcinoma Cells
- Chiral Relevance of Stereoselective Disposition of Proton Pump Inhibitors:Comparision of Lansoprasole to Omeprazole and Pantoprazole
- In silico High-Throughput Screening by Hierarchical Chemical DB Search by 3D Pharmacophore Model
- Enantiomer Separation of Chiral Drugs on HPLC Chiral Stationary Phases
- Protective effect of Platycodon grandiflorum against t-butyl hydroperoxide-induced hepatic toxicity in rats
- A NAT for reliable HCV RNA detection from plasma and plasma-derived medicinal products
- Examination of alginate/PEI/DNA polyplex as a gene delivery system：enhancing transfection efficiency in the presence of serum and reducing cytotoxicity
- A Novel and Highly Potent Non-vanilloid VR Antagonist
- Analysis of vasopressin-induced Ca2+ influx in rat hepatocytes
- Effect of Synthetic Bile Acid Derivatives on the Cell Cycle Modulation of HT-29 Human Colon Cancer Cells
- COX-inhibitors down-regulateTCDD-induced cyp1a1 activity in C57BL/6 mouse and Hepa-I cells
- Dissolution Test for Indomethacin by the Portable Near-lnfrared(NIR) System
- Cellular Factors Involved in Methylmercury Toxicity in Yeast
- Effects of Platycodi Radix on dimethylnitrosamine-induced hepatic fibrosis in rats
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