학술논문
Proteomics in Drug Discovery
이용수 0
- 영문명
- 발행기관
- 대한약학회
- 저자명
- W. Rodney M athews
- 간행물 정보
- 『추계총회 및 학술대회』(2002년) vol.2, 73~73쪽, 전체 0쪽
- 주제분류
- 의약학 > 내과학
- 파일형태
- 발행일자
- 2002.10.30
무료
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
The study of the protein complement of the genome, or proteome, represents an important new avenue for drug discovery. Proteomics research aims to quantify and characterize all of the expressed proteins in a biological system, and to determine the effect of various perturbations of the system on the expressed proteins. The resulting protein expression data can then used to help discover and characterize new drug targets, evaluate the mechanism of action of lead compounds, and investigate potential toxicity of novel therapeutic agents. A critical aspect of proteomics is protein identification. Mass spectrometry enables rapid identification and characterization of expressed proteins and bridges the gap between genome and proteome. A flexible, high performance protein identification system based on commercially available instrumentation has been assembled and implemented. The performance of the system, including validation with protein standards and its application to real world problems in drug discovery will be described.
목차
키워드
해당간행물 수록 논문
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- Accurate Chiral Discrimination of Acidic- and Amino acidic-Chiral Drugs by Indirect GC and Direct CE Enantiomeric Separation Methods
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- Efficient Solid Phase Library Synthesis of 7-Alkoxy-1,3,4,5-tetrahydro-benzo [e][1,4] diazepin-2-one
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- Neuroprotective effect of wogonin in a rodent model of permanent focal cerebral ischemia
- Determination of the water content in Citrus leaves by portable near in frared (NIR) system
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- The Effects of Oral Administrations of Panax ginseng and P. quinquefolium on Hemodynamics and Body Temperature in Healthy Young Men : Results of Single Blind Test
- A convenient synthesis of 2' or 3'-amino-2'(or 3')-deoxyadenosine and 5'-chloro-2' (or 3')-amino-deoxyadenosine analogues
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- Stereoselective synthesis of novel 4'α-C-methyl branched novel carbocyclic nucleosides
- Biochemical analysis of a high-molecular-weight protease from Streptomyces tendae JC412
- Asymmetric Synthesis of 12(S)-HETE
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- Further Studies on Anti-angiogenic Activity of Gardenia jasminoides Fruit
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- Cloning, Sequencing and Characterization of the Novel Penicillin G Acylase Gene from the Soil-isolated Ledercia adecarboxylata
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- Anti-inflammatory, analgesic, and hypouricemic effect of Actinidia polygama(AP)
- Synthesis and Antiinflammatory Activity of 1,5- and 4,5-Disubstituted Imidazoles
- Purification and Chracterization of fibrinolytic enzymes from Vegetable warms
- THE RELATIONSHIP OF INTESTINAL ABSORPTION CLEARANCE AND PARTITION COEFFICIENT OF NINE BETA-BLOCKERS IN RATS
- Pharmacokinetics of New Solubilizer in Intravenous Micelle Formulation of Paclitaxel in Mice
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- Antimicrobial effects of ocotillone isolated from the stem bark of Ailanthus altisshima
- Synergistic effect of a mixed herbal extract on bone loss in ovariectomized (OVX) rats
- Structural Requirement of Isoflavonones for the Inhibitory Activity of Interleukin-5
- Chemiluminogenic imaging for highly sensitive detection of DNA
- Synthesis of 3-arylisoquinolinamines and 3D-Quantitative Structure Activity Relationships Study
- Enhanced p53 Gene Transfer to Human Ovarian Cancer Cells using Cationic Nonviral Vector, DDC
- Isolation of inhibitors of NF-κB activation by UV stimuli in transfectant HaCaT cells from Acanthopanacis sessilifflorum
- Tyrosinase and melanin biosynthesis inhibitory activities of crude drugs
- Transforming Growth Factor-β(TGF-β) Induces Invasion and Migration of Ras-Transformed MCF10A Human Breast Epithelial Cells
- Study on antifungal activity of herb oils against Trichophyton spp
- HPLC Determination of Loratadine in Human Plasma with UV Detection and Pharmacokinetics of Loratadine Following Oral Administration of Tablet Formulation in Human
- In vitro and in vivo transfection efficiency of a cationic lipid containing sodium cholate
- Design, Synthesis and Antitumor Evaluation of Terpyridine Derivatives Containing Pyridines at 4'-Position
- Apicidin Induction of cyclin E might be mediated by Sp1 Transcription Factor
- New tsaokoin isomer with antifungal activity from the plant Amomum tsao-ko
- Cytotoxicity and Antimutagenic Activity of the Thorns of Gleditsia sinensis Lam
- Cytotoxic Constituents from Amanita pantherina(DC.ex Fr.) Krombh
- The Versatile Conversion of Acyclic Amides to a-Alkylated Amines
- Alternation of Adhesion Molecules during Aging and Modulation by Calorie Restriction
- Molecular Dynamics Simulation of Enantioselectivity in Metoprolol in complex
- Computer-based screening for novel inhibitors of human topoisomerase I with FlexiDock docking protocol
- In vitro Antiinflammatory Activity of the Essential oil Extracted from Chrysanthemum sibiricum in Murine Macrophage RAW 264.7 Cells
- EFFECTS OF ISOTHIAZOLE AND ISOXAZOLE DERIVATIVES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS
- Study on the inhibition of Whole Blood Plateiet-Aggregation and antioxidative effects from Rhus verniciflua Stokes
- Structure-Activity Relationship Study of Asiatic Acid Derivatives for New Wound Healing Agent
- Role of Kupffer Cells in Hepatic Drug Metabolizing Dysfunction during Polymicrobial Sepsis
- Regioselective Substitution of 6,7-Dichloroquinoline-5,8-dione: Synthesis, Cytotoxicity, and X-ray crystal stucture of 4a, 10,11-Triazabenzo[3,2-a]fluorene-5,6-diones
- Assay of Human Chorionic Gonadotropin in Urine of Athletes and Evaluation of Assay Kit Performance
- POPULATION PHARMACOKINETICS OF TERBINAFINE IN HEALTHY MALE KOREAN SUBJECTS USING NONMEM
- Pharmacodynamics of anticancer activity of tirapazamine and paclitaxel against human NSCLC
- Synthesis of 14C-Radio Isotope Labeled Quinolone Intermediates
- Curcumin Inhibits Phorbol Ester-induced Expression of Cyclooxygenase-2 In Suppression of Extracelluar Signal-regulated Kinase(ERK)1/2 and NF-κB in Mouse Skin
- Current Status of Medication Counseling Service at Community and Hospital Pharmacies in Korea Based on Nation-wide Survey Research in 2002
- Developement of Quantitative Extraction Method of Amygdalin without Enzymatic Hydrolysis from Tonin(Persicae Semen) by High Performance Liquid Chromatography
- Synthesis and Biological Evaluation of Pyrimidine Nucleosides Fused with 3',4'-Tetrahydrofuran Ring
- Two new acylated neoline derivatives from Aconiti Tuber
- DESIGN AND SYNTHESIS OF A3 ADENOSINE RECEPTOR LIGANDS. 2'-FLUORO ANALOGUES OF Cl-IB-MECA
- Tissue Distribution of Novel Polymeric Micellar Paclitaxel in Mice
- Ligand-Based Virtual Screening for inhibitors of PTP-1B with Antihyperglycemic properties
- Anti-oxidant activities of the extracts from the herbs of Artemisia apiacea
- Simultaneous determination of seven major human cytochrome P450 activities using LC/MS/MS
- Screening and Confirmation of Designer Drugs and Anorectics in Urines using Immunoassay and GC/MS
- Attenuation of monocrotaline-induced pulmonary hypertension with DA-8159, a potent PDE 5 inhibitor
- Tyrosinase Inhibiting and DPPH Radical Scavenging Activities of Rosmarinic Acid and Its Methyl ester from Salvia miltiorrhiza
- Protective effect of KR-32000 against hypoxia-and oxidative stress-induced cardiac cell death
- β-ketoacyl-acyl carrier protein synthases for fatty acid biosynthesis in bacteria
- Inhibitory effects of new quinone compounds on eNOS activity in rat aorta and nNOS activity in rat brain
- The Lipidperoxidative effect of Houttuynia cordata Thunb & Saururus chinensis
- Effects of aqueous extract isolated from Platycodon grandiflorum against oxidative stress in rat primary hepatocytes
- TOLERANCE AND PHARMACOKINETICS OF SINGLE-DOSE DA-8159, A SELECTIVE PDE5 INHIBITOR. IN HEALTHY MALES
- Neuroprotective effects of baicalein, baicalin, and wogonin in primary cuItured rat cortical cells
- Revisit to Unfulfilled Premise of Arylsulfonylimidazolidinones as Anticancer Agent
- Anti-asthmatic agents of Gastrodia elata Rhizoma MeOH extracts
- Simultaneous Determination of Underivatized Diazepam and Nordiazepam in Plasma Using Gas Chromatography/Mass Spectrometry
- Induction of penile erection in spinal cord-injured rabbits by administration of DA-8159, a new selective PDE 5 inhibitor
- Genetic Effects on Exposure to Polycydic Aromatic Hydrocarbons in a Korean Population
- Qualification of various polymorphs by near-infrared(NIR) spectrophotometer
- IL-12 Expression by Cefodizime As an Immuno-modulator
- Assay Validation of Lansoprazole in Human Plasma
- Sexual Dimorphic Effects of Terbufos on Acetylcholinesterase and Lethality
- Synthesis of Azaisoflavones and Evaluation of Their Inhibitory Effects on lL–5
- 5~Arylidene-2(5H)-furanone Derivatives: Synthesis and Structure-Activity Relationship toward Cytotoxicity
- Erk activation mediates mediates lipopolysaccharide-induced induction of matrix metalloprotease-9 from rat primary astrocytes
- Synthesis of Novel 3-Aminohydantoinyl-1,2-benzothiazine Derivatives for the COX-2 inhibitors
- Identification of a 68kDa cytosolic, neutral and Mg2+-independent Sphingomyelinase by MALDI-TOF Analysis
- Biomolecular Mechanism of Cadmium Toxicity
- ROLES OF PGE₂AND 15-DEOXY-Δ¹²,¹⁴PROSTAGLANDIN J₂IN ET-18-O-CH₃-INDUCED INFLAMMATORY CELL DEATH
- Antidiabetic effect and mechanisms of SPH-2 in db/db mice
- Development of a high-performance liquid chromatographic method for the determintion of levosulpiride in plasma
- Tacrolimus and cyclosporine A inhibit both class I-restricted presentation pathway and classⅡ-restricted presentation pathway of exogenous antigen
- Submicrosecond dynamics of nucleic acids studied with a long-lifetime metal-ligand complex
- Microglial activation and tyrosine hydroxylase immunoreactivity in the substantia nigral region following transient focal ischemia in rats
- Proficiency Test for Pharmaceutical Companies in Analyzing Drug Products (I) - Comparison of Criteria for Satisfactory Test Results
- Aluminium increase Iron uptake into Glial cells
- Three Cytotoxic compounds isolated from the seeds of Pharbitis nil
- Effects of pyrethroid compounds on alkaline phosphatase activity in estrogen receptor positive human breast cancer cells
- Isolation of α-Glucosidase Inhibitor Producing Soil Microorganism and Inhibitory Effects of Microbial Metabolites on α-Glucosidase
- 23-hydroxyursolic acid Induces Apoptosis of human leukemia HL-60 cells
- Nonviral Vector for Efficient Gene Transfer to Human Ovarian Adenocarcinoma Cells
- The properties of ginseng saponins metabolizing intestinal bacteria
- The first synthesis of 4'α-C aryl branched carbocyclic nucleosides
- Osteoanagenesis Effect Of Hwang-Chil. a natural resources of Korea
- Decursin derivative-004 protect renal cell damage via p38 MARK inhibition
- Proteomic Analysis of Gastric Cancer Patient Sera
- CoMFA of 1-phenyl-2-substituted thioureas for their cytotoxicity
- ZR-75-1human breast cancer cells to study the mechanism of action of PAHs
- Production, purification and characterization of extracellular protease from Streptomyces scabiei subsp. chosunensis M0137
- Vitamin K Antagonist, NQ12 Inhibits PDGF-BB-lnduced MAP Kinases Activation in Rat Aortic Vascular Smooth Muscle Cells
- A new strategy for high productivity of Erythropoietin in CHO cell by introducing urea cycle enzymes
- In vitro mutagenicity and genotoxicity study of PAHs and nitro-PAHs using the bacterial revertant (Ames) test and alkaline single cell gel electrophorosis (Comet) assay
- Effect of the Extract of Cultured Ginseng Roots on Hyperlipidemia in Rats
- Studies on the Analysis of Anti-impotent Drugs (Ⅱ) - Rapid analysis of Sildenafil and modified Sildenafils using HPTLC
- Lead Discovery and Optimization towards FXR Specific Compounds
- Binding modes of artemisinin to malarial TCTP demonstrated by computer modeling
- Anti-proliferative Effects of Ixeris sonchifolia H. Extracts on Human Hepatocellar Carcinoma Cells
- Immunomodulatory activity of a polysaccharide isolated from cell culture of Acantopanax senticosus
- Analysis of bufotoxins in toad venom and toad eggs
- Synthesis and Evaluation of Biological activities of New Imine Derivatives of Apicidin
- Protective effect of metabolized Yangguksanwha-tang on Hypoxia/Reperfusion induced-PC12 cell damage
- Chiral Separation of Aromatic Acids by Capillary Electrophoresis Using HP β-Cyclodextrin as the Chiral Selector
- Antihyperlipidemic effect of Alpinia oficinarum
- Pathogenic and immunological properties of alcohol dehydrogenase in Streptococcus pneumoniae
- Simultaneous determination of thirteen cosmetic preservatives in skin creams by HPLC-PDA method
- Chiral discrimination studies of (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid by NMR spectroscopy
- Total synthesis of Antofine by using Intramolecular 1,3-dipolar cycloaddition of Azidealkene
- Mn²+ dependent ClpL ATPase in Streptococcus pneumoniae
- IN VIVO METABOLISM OF 2-METHYLAMINOETHYL-4,4'-DlMETHOXY-5,6,5',6'-DIMETHYLENEDIOXYBIPHENYL-2-CARBOXY-2-CARBOXYLATE (DDB-S) BY LC/ESI TANDEM MASS SPECTROMETRY
- Inhibitory Effects of 1,3-Selenazol-4-one Derivatives on Mushroom Tyrosinase
- Quantitative determination of pseudoephedrine in human plasma by reversed-phase liquid chromatography-electrospray ionization mass spectrometry
- Potentiometric Characteristics of Metal(Ⅱ)-Triethylene tetramine-Acidic Drug Membrane Electrodes
- Development of economic preparative method of (S)-(+)-enantiomer of arylpropionic acids
- Safety pharmacology study of AS2-006A, a new wound healing drug
- Transcriptional Responses of Respiratory Epithelial Cells to Nontypable H. influenzae Infection: Identification of Differentially Regulated Genes by Microarray Analysis of Human cDNA
- Development of rapid, sensitive and reproducible paraquat analysis method in the postmortem specimens
- Development of a New Gut-targeted Oral l^phoid Vaccine Ty21a
- HPLC Resolution of Enantiomers Using Polysaccharide Derivatives as Chiral Stationay Phases
- Pharmacological actions of H2O and MeOH extract of Opuntia ficus-indica Semen
- The Immunogenic Peptide for Thl Development and Its Adjuvant Activity
- Anti-inflammatory Action of Calorie Restriction for Life-Prolongation: A Possible Mechanism
- The Antiproliferative Effects of Bile Acids and Their Derivatives on HepG2 Human Hepatocellular Carcinoma Cells
- Chiral Relevance of Stereoselective Disposition of Proton Pump Inhibitors:Comparision of Lansoprasole to Omeprazole and Pantoprazole
- In silico High-Throughput Screening by Hierarchical Chemical DB Search by 3D Pharmacophore Model
- Enantiomer Separation of Chiral Drugs on HPLC Chiral Stationary Phases
- Protective effect of Platycodon grandiflorum against t-butyl hydroperoxide-induced hepatic toxicity in rats
- A NAT for reliable HCV RNA detection from plasma and plasma-derived medicinal products
- Examination of alginate/PEI/DNA polyplex as a gene delivery system：enhancing transfection efficiency in the presence of serum and reducing cytotoxicity
- A Novel and Highly Potent Non-vanilloid VR Antagonist
- Analysis of vasopressin-induced Ca2+ influx in rat hepatocytes
- Effect of Synthetic Bile Acid Derivatives on the Cell Cycle Modulation of HT-29 Human Colon Cancer Cells
- COX-inhibitors down-regulateTCDD-induced cyp1a1 activity in C57BL/6 mouse and Hepa-I cells
- Dissolution Test for Indomethacin by the Portable Near-lnfrared(NIR) System
- Cellular Factors Involved in Methylmercury Toxicity in Yeast
- Effects of Platycodi Radix on dimethylnitrosamine-induced hepatic fibrosis in rats
- Induction of apoptosis in human promyelocytic leukaemia HL-60 cells by manassatin B involves release of cytochrome c and activation of caspases
- Synthesis and Characterization of Polyamines and Their Metal Complexes
- Pharmacokinetic and Pharmacodynamic Modeling of a Proton Pump Inhibitor
- Recent Developments in Analytical and Preparative Scale Enantioseparations
- Anti-inflammatory Effect of Hederagenin Glycoside Isolated from Lonicera japonica
- Control of Influenza: Live Vaccine Development
- Antidiabetic effect and mechanisms of SPH-1 in db/db mice
- Role and Action Mechanism of Secretory phospholipase A2 in Macrophage Activation
- Cholinergic involvement of spatial memory impairment in μ-opioid receptor knockout mice
- Chemopreventive and Chemoprotective Potential of Naturally Occurring and Synthetic Anti-inflammatory Agents
- Establishment of new cytotoxicity screening system using Caco-2 cells
- Effects of Sustained-Release Formulation of Recombinant Human Growth Hormone on Body weight, Bone growth and Organs in Hypophysectomized Rats
- Molecular interaction of Gα16 subunit G protein with chemoattractant receptors
- Comparison of CE and HPLC as analytical methods of (-)-yatein enantiomer from Cupressaceae plants
- The Effect of Chondroitin Sulfate against Oxidative Stress and Atherosclerosis in Ovariectomized Rat
- Neuroprotective Mechanisms of Atoesin against Focal Ischemic Brain Injury
- Saponins Isolated from the Leguminosae Plants
- The anti-inflammatory activity of Kalopanax pictus bark extract (IV). Antirheumatic activity of kalopanaxsaponin A methyl ester
- Induction of Apoptosis by N-phenyl-O-phenylthionocarbamate substitutes in SK-MEL-28 human skin cancer cell line
- A newly antiarrhythmic drug CW-2202 is ideal in treating atrial fibrillation
- Immune responses to synthetic peptides of RSV F protein
- Synthesis of Benzoquinoxalines
- Preparation of polymeric nanoparticles from hydrophobically modified pullulan for hydrophobic drug carrier
- Characterization of the rhGHr eleased from rhGH-loaded PLGA microspheres
- A Comparatives study for single-shot immunization of diphtheria toxoid with combined PLGA microspheres
- Transport of Organic Cations across Caco-2 Cell Monolayers
- Standardization of uniformity of dosage unit for oral dosage forms
- Solid Lipid Nanoparticles(SLN) as Controlled Release Subcutaneous Injections of Local Anesthetics
- Preparation and release characteristics of PVP-based solid dispersion capsules containing solubilizers
- DESIGN. SYNTHESIS AND IN VITRO EVALUATION OF APIO ANALOGUE OF NEPLANOCIN A
- Depth-profiling of skin in the near infrared using fiber optic probes
- Dexamethasone 21-sulfate sodium ： A potential colon-specific prodrug of dexamethasone
- Pipeline, a Primary Component of Black Pepper, inhibits Prostagladins Generation by Suppression of COX Activity on Arachidonic Acid Metabolism in LPS-Stimulated RAW264.7 Cells
- Inhibitory effect of 2-amino-3-ethoxycarbonyl-1-methyl pyrolo (3,2-b) naphtho-4,9-dione on tumor cell invasion in human fibrosarcoma cells by downregulating matrix metalloproteinase-2 and 9
- Comparisons of thermogenic activity among Ginseng Radix Alba (GRA), Ginseng Radix Rubra (GRR), and Panax Quinquefolii Radix (PQR)
- Sphingosine-1-phosphate Promotes the Survival of Mel-Ab Cells via ERK and Akt activation
- Assessment of allergenicity of genetically modified foods (GMOs)
- Induction of apoptosis in human promyeiocytic leukaemia HL-60 cells by yomogin involves release of cytochrome c and activation of caspase
- Tyrosine kinase inhibitors reverse lawsone methyl ether stimulation of renal dipeptidase release but not of alkaline phosphatase release
- Proteome Analysis of Apicidin-Treated Human Cervix Cancer Cells
- Effect of porcine testis-derived glycosaminoglycans on blood coagulation and immune responses
- Stable expression of N-terminal 3X-FLAG tagged human 5a-reductase type II in 293 cells：a new tool for protein purification & inhibitor screening
- Synthesis of 2,6-Diaromatic Substituted Pyridine Derivatives and Their Antitumor Activities
- Stability of the current biological drugs(typhoid vaccine)
- Synthesis of Selenoflavonoid and Selenoisoflavonoid
- 3,4-Diaryl-2(5H)-Furanone Derivatives: Synthesis, Cytotoxicity, and Antitumor Activity
- Antioxidant compounds from the twig of the Morus alba L.
- Phenolic Compounds from Barks of Pinus densiflora siebold et Zuccarini and Their NO Production Inhibitory Activities
- Butyrylcholineesterase(BChE) Inhibitors froma Brown Alga Sargassum sp.
- A Specific butyrylcholinesterase inhibitor from the fruits of Evodia officinalis
- Antioxidative activity of compounds from cuItivated Phellinus linteus
- Isolation of the ppar-y ligands from the stem of the Zanthoxylum Schinifolium and their structure activity relationships
- Simultaneous Determination of Curcumin and Glycyrrhizin Contents by High-performance Liquid Chromatography in Two Different Oriental Herbal Preparations of Kamijadowhan
- Anti-Oxidative compounds from Quercus salicina bark
- Effect of P-020701 on gastric lesion and ulcer in rats
- Triterpene Components from the Leaves of Acanthopanax sessiliflorus
- Regulation of the absorption of dietary sugar by α-glucosidase inhibitors from herbal medicines
- Xanthorrhizol inhibits pro-inflammatory mediators in mouse macrophage cells
- Transfersomes-mediated gene transfer into organs in mice by direct application on intact skin
- Effect of Polyethylenimine Type in Polylactic acid Nanoparticles/DNA Complex on the Transfection Efficiency
- Clinical Effects of Gemcitabine and 5-Fluorouracil Combination therapy and Epirubicin, Cisplatin, and 5-Fluorouracil Combination therapy for patients with Pancreatic Cancer
- Protection of Paeoniae radix from H2O2-induced oxidative DNA damage
- Effects of chitosan on the decreased renal dipeptidase release by nitric oxide from renal proximal tubules
- The 3-D QSAR study of antitumor arylsulfonylimidazolidinone derivatives by CoMFA and COMSIA
- In vitro Antitumor Activity and Nephrotoxicity of Pt(ll) Complexes Containing Diaminocyclohexane
- Terpenoids from Artemisia rubripes Nakai
- Studies on the constituents of the aerial part of Gastrodia elata Blume
- Development of Immunostrip for DDT Detection
- Analysis of the chemical burn-inducing components from the extraction of herb drug-mixed-medicine
- Mucoadhesive Drug Carrier Using Poly(acrylic acid)/poly(vinyl alcohol) Interpolymer Complexes by Template Polymerization
- Pharmacokinetics of DA-3021 (mono-PEGylated recombinant human interferon α-2a) after Subcutaneous Administrations to Experimental Animals
- Genetic Suppressor Elements that Halt the Proliferation of Breast Carcinoma Cells.
- In Vivo Roles of Lysophospholipid Receptors Revealed by Gene Targeting Studies in Mice
- In vitro Antiinflammatory Activity of 23-Hydroxyursolic Acid Isolated from Cussonia bancoensis in Murine Macrophage RAW 264.7 Cells
- Induction of apoptosis by benz[f]indole-4.9-dione analog in human lung cancer cells through p53-depencient mechanism
- Evaluation of electroretinogram and retinal histopathology in rabbits administered DA-8159, a selective PDE 5 inhibitor
- Changes of serum immunogiobulin in the subacute oral administration of bisphenol A
- Comparative Stuies on the Detection of Drug-Toxic Substances in the Formalin Fixed and Unfixed Tissue Specimens
- Chronic exposure of nicotine modulate the expressions of cerebellar glial glutamate transporters in rats
- In utero exposure to 2.3'.4.4', 5-Pentachlorobiphenyl (PCS 118) alters postnatal reproductive development in female rat
- Antiplatelet Activity of NQ12 May Be Mediated by Inhibition of Cyclooxygenase and Generation of 12-HETE
- Allicin reduces expression of Intercellular Adhesion Molecule-1 (ICAM-1) in gamma-irradiated endothelial cells : Involvement of p38 MAP kinase signalling pathway
- Diasteroselective synthesis of long chained keto amino acids derivatives
- Anti-angiogenic activity of conjugated linoleic acid on the basic fibroblast growth factor-induced angiogenesis
- The ermk leader peptide alterations leading to differential efficiency of induction by erythromycin
- A new 4-hydroxy-dodec-2E-enedioic acid from the stem bark of Albizzia julibrissin
- Discrimination of Cnidium Rhizome using PCR-mediated RFLP
- Chiral Synthesis of Costunolide
- Studies on the Analysis of Anti-impotent Drugs
- Determination of triflusal in human plasma by high performance liquid chromatography with automated column switching system
- Determination of Histamine in a Pharmaceutical Preparation after Clean-Up by Solid–Phase Extraction
- Proficiency Test for Pharmaceutical Companies in Analyzing Drug Products (Ⅱ) - Analysis of Variance of Factors Influencing Test Results
- Adenosine inhibits the death in immunostimulated murine astrocytes deprived of glucose
- A Collaborative Study to Establish a Korea National Biological Standard for Antithrombin Concentrate
- DA-7911, rhenium-188(Re188) tin colloid, as a strong candidate agent for radiation synovectomy
- Comparison of CYP 3A4 metabolism between DA-8159 and Sildenafil in vitro and in vivo
- Mechanism of immunostimulating action of polysaccharide isolated from Platycodon grandiflorum in RAW 264.7 macrophages
- Pharmacology of novel vanilloid receptor antagonists
- Metallothionein gene expression in different tissues of Crucian carp (Carassius auratus) exposed to cadmium chloride
- Quercetin analogs extracted from Lidera erythrocarpa protects heart-derived H9c2 cells from oxidative stress-induced death
- The modulating activity of Ginsan on radiation-induced disturbance of antioxidant defense systems
- Anti-/pro-apoptotic regulatory potentials of LPS/IFN-y in the mulnutrition induced macrophage
- Additional Sesquiterpene Lactones from Ixeris sonchifolia
- Five compounds from leaves of Hovenia dulcis T
- Analysis of DA-6034, a New Flavonoid Derivative in Biological Fluids by Fluorescence Detector
- Narrowbore high-performance liquid chromatographic method for the determination of cetirizine in plasma using column switching
- Enantiomeric Profiling Analysis of NSAIDs by Capillary Electrophoresis Using TM β-Cyclodextrin as the Chiral Selector
- Chiral separation of β-blockers after derivatization with a new chiral derivatization agent, GATC and Comparison with GITC on derivatizing conditions and chromatographic parameters
- Immunomodulatory activity of acharan suIfate isolated from Achatina fulica
- Action of lysophosphatidylcholine in U937 human monocytes
- The anti-inflammatory activity of Kalopanax pictus bark extract (V). Effects of saponins from KP on NF-κB and elastase activities
- The Screening of Hepatic Functional Improvement, Liver Protection and Antifibrotic Effect from Dried Extracts of Concha Cipangopaludinae
- Inhibitory effects of a new iridoids, patridoid I and II on TNF, iNOS and COX-2 expression in cultured murine macrophages
- Intranasal Vaccination with Conjugate Vaccines Protects Against Invasive Disease Caused by Encapsulated Bacteria entering the Body Via the Respiratory Mucosa.
- GREEN TEA EXTRACT INHIBITS CATECHOLAMINE RELEASE IN THE PERFUSED RAT ADRENAL GLAND
- Solution-Phase Synthesis of a Library of Biaryl Amides Using Girard's reagent T as an Acid Chloride Scavenger
- Pharmacokinetic Scaling of SJ-8029, a Novel Anticancer Agent Possessing Microtubule and Topoisomerase Inhibiting Activities, by Species-lnvariarit Time Methods
- The Production of IFN-y by 3LL/TNF-α-Activated Macrophages Requires p38. JAK-2 Signalling and is Enhanced by New Protein Synthesis
- A New Synthesis of Hydantoin derivatives by the Reaction of Unnatural Amino acids with Potassium Isocyanate
- Anticancer and Antiviral Effect of Some Triterpenes Isolated from the Natural Sources
- Rapid Analysis of Metabolic Stability and Structure of Metabolites in New Drug Development
- The Applications and The evaluation Methods for the Brain Uptake and Delivery of Candidates of New Drug
- Phenolic Compounds from Barks of Ulmus macrocarpa and Their Antioxidative Activities
- High Throughput Screening System for Kinetics of Brain Influx
- Targeting of Large-molecule Radiopharmaceuticals across the Blood-brain Barrier Using Endogenous TVansport Systems
- Cell signaling and therapeutic drug target for the treatment of liver cirrhosis
- Proteomics in Drug Discovery
- Hepatobiliary Transport: Mechanisms, QSAR and Regulation
- A new mechanism for unsaturated fatty acid biosynthesis in Streptococcus pneumoniae
- Concentrations of Dextromethorphan in Urine and Blood of Two Crime Suspects
- Metabolic Activation of Marijuana Constituents, Caimabinoids, in Relation to Their Toxicity for Human and Its Oxidation Mechanism
- Immunosuppressive activity of Allergina
- Effects of ascorbic acid according to administration doses on radiation induced DNA damage in mouse splenic and blood lymphocytes
- Comparison of Ginsenosides Composition in Various Panax Ginseng Roots Cultivated in Different Places and Years
- Comparative Studies of Molecular Mechanisms of Dopamine D2 and D3 Receptors for the Activation of Extracellular Signal Regulated Kinase 1/2 in HEK-293 cells
- Environmentally benign, Background-free protein staining in SDS-polyacrylamide gels using an counter ion-dye complex solution
- Epigallocatechin Gallate inhibits Prostagladins Generation by Suppression of cPLA2 Activity on Arachidonic Acid Metabolism in LPS-Stimulated RAW264.7 Cells
- Inhibitory Effects of Natural Plant extracts on ICAM-1/LFA-1Mediated Adhesion of HL-60 Cells
- Inhibition of C2-ceramide induced contraction in cat esophageal smooth muscle cell by newly synthesized Ceramide analogues
- Relationship Between Flavonoid Structure and Inhibition of Farnesyl Protein Transferase
- Culture of rabbit chondrocytes on the HA-agarose scaffold for artificial cartilage
- Levels of organochlorine pesticides and PCB congeners in Korean human tissues
- Application of in situ gelling mucoadhesive delivery system for plasmid DNA as a macromolecule
- Neuroprotective Effects of Treatment with Aloesin in Rat Model of Permanent Focal Cerebral Ischemia
- Modulation of carcinogen-activating enzymes by synthetic trans-stilbene analogs
- Differential Protein and Gene Expression after Adenovirus-Mediated p16 Gene Transfer in Human Non-Small Cell Lung Cancer Cells
- Orphan G Protein-coupled Receptors in Post-Genome Era
- Site-specific PEGylation of Peptide Drugs
- Mechanistic Pharmacokinetic/pharmacodynamic Modeling in Isolated Perfused Organs and at the Whole-Body Level
- Synthetic study of costunolide
- Inhibitory effects of resveratrol analogs on lipopolysaccharide-induced cyclooxygenase-2 activity in RAW 264.7 cells
- Revers phase HPLC Separation of D-Amygdalin and Neoamygdalin and Optimum Conditions for Inhibition of Racemization of Amygdalin
- High-Throughput Screening for Novel Inhibitors of Protein-Tyrosine Phosphatase-1B
- Arachidonic Acid Liberated through Activation of iPLA₂Mediates the Production of Reactive Oxygen Species and Apoptosis Induced by N-Ethylmaleimide in HepG2 Human Hepatoma Cellls
- PLATYCODIN D, NOT D3, CAUSES VASODILATATION IN THE RAT
- Report on the trends of the Drug Abuse and the Mortalities related to Intoxication of Drug-Toxic Substances in the Central Area of Korea in 2001
- Studies on the protective effect of Cheju and Brazil pectin on the male reproductive system damaged by 2.3.7.8-tetrachlorodibenzo-P-dioxin
- Down-regulation of inducible nitric oxide synthase and tumor necrosis factor-a expression by Bisphenol A via nuclear factor-kB inactivation in macrophages
- Estrogenic Activities of Pyrethroid Compounds in MCF-7 BUS cells
- Effect of oral administration of Ginsenoside-Rb2 on rotavirus infection
- non-viral gene delivery mediated by chitosan and PEI ： developement of a gene carrier with serum stability and reduced cytotoxicity
- Ceramide analogs inhibit inducible nitric oxide synthase expression and nitric oxide production in interferon-gamma and lipopolysaccharide-stimulated RAW 264.7 macrophages
- Isolation, structure, and NF-kB modulatory activity of Harziarum A and B: trichothecene from fungi (B000527)
- GDNF Enhances Hs683 Human Glioma Cell Migration：Possible Involvement of MAPKs
- Inflammation, Injury and Transcription Factors in Chronic Lung Diseases: Therapeutic Targets
- Diastereoselective Synthesis of (+)-Frontalin
- Analysis of Branched PEG-Conjugated Interferon Alpha by Capillary Electrophoresis and MALDI-TOF Mass Spectrometry
- Comparison of isoBOC derivatives, TBDMS derivatives, with US EPA Method in the sensitivity of Alkylphenols, Chlorophenols, and Bisphenol A potential field-screening applications of GC/MS-SIM
- Phosphatidylinositol 3-Kinase Regulates Nuclear Translocation of NF-E2-Related Factor 2 through Actin Rearrangement in Response to Oxidative Stress
- Selective B cell activation by polysaccharide isolated from the root of Acanthopanax koreanum
- Inhibitory Effect of Luteolin on TNF-α-Stimulated IL-8 Secretion from Intestinal Epithelial Cells
- Chemopreventive effect of Ginkgo biloba extract on breast cancer : Regulation of estrogen level
- An investigation of the effect of epigallocathechin-3-gallate on the renal dipeptidase release
- Role of phospholipid metabolism in Methylmercury-induced Cytotoxicity
- Toxicological Evaluation of Oriental Herbal Medicine Kamijadowhan Preparations
- The effect of some natural products on mouse melanoma cells in vitro
- An In Vitro Bioassay for Nerve Growth Factor
- Studies on standardization and characterization of recombinant interferon alfa
- Decusinol angelate inhibits UVB-induced MMP-1 induction via Mitogen-activated Protein Kinase Pathway in human skin fibroblasts
- Cleavage of Benzyl and p-Methoxybenzyl Ethers Using Chlorosulfonyl Isocyanate Reaction
- Chiral Separation of Non-Steroidal Inflammatory Drugs and Metabolites by Achiral Gas Chromatography as O-Trifluoroacetylated (-)-Menthyl Esters
- Optimization of a fiber optic probe for non-invasive blood glucose monitoring
- Drug Use Evaluation of Hypoglycemic Agents in Type 2 Diabetes
- An Anti-cancer Drug, Paclitaxel, Induces Apoptosis in MCF-7 Human Breast Cancer Cells by Generating Ceramide and Arachidonic Acid
- Development of a new Cox-2 inhibitor as an anticancer agent
- Pharmacokinetic and Pharmacodynamic Modeling of Levodopa in Parkinson Disease
- Pharmacokinetic and Pharmacodynamic Characteristics of Cyclosporin A in Rats and Rabbits
- Effect of Drugs on the Cardiac Transport, Metabolism and Action of Idarubicin: Pharmacokinetic and Pharmacodynamic Modeling
- 4-Hydroxy nonenal (HNE) Induces Apoptosis and Cell Cycle Arrest in Bovine Aortic Endothelial Cells
- Effects of cationic polyamines under 10 kD range of molecular weight on basic and induced mucin release from airway goblet cells
- Changes of serum immunoglobulin in the subacute oral administration of Mancozeb
- Effects of Protein Kinase Inhibitors on Histamine Release and ROS Generation in RBL 2H3 Cells
- Design and Synthesis of Benzoquinoxalinediones
- Ginsenosides Content of The Manufactured Ginseng Radices Extracts
- Algorithm for finding the best regression models using NIR spectra
- Does Agitation Condition Affect the Correlation Between in vitro Permeability of Xenobiotics across Caco-2 Cells and in vivo Bioavailability of the Compounds?
- Hypoglycemic Effect of Ginseng Radix alba(GRA) in Multiple Low Dose Streptozotocin-induced Diabetic Rats
- Studies on Anti-inflammatory effect of Clerodendron trichotomum Thunberg Leaves
- Activation of mouse macrophage cell line by aloe gel components：The carbohydrate fraction from Aloe vera gel
- Synthetic Approaches to Benzophenanthridines
- Regio- & Stereoselective Synthetic Method for Polyhydroxyamines using Chlorosulfonyl Isocyanate
- A novel triterpene saponin from the roots of Platycodon grandoflorum
- On the Contents of Alkaloids in the Cho O by Processing Methods
- lontophreotic delivery of vitamine-C-2-phosphate
- Total synthesis of deoxy-azasugars
- Antitum or activity of oxaliplatin, 5-FU and paclitaxel given alone and in combination with ZD1839 in human gastric carcinoma cells in vitro
- The pharmacological effect of the methanol extracts from Acanthopanax senticosus after immobilized and chronic swimming stresses in rats
- Roles and signaling pathway of M2 pyruvate kinase in RBL-2H3 cells
- Histamine Releasing Factor (HRF) Evokes [3H]Dopamine Release by a Ca²+ -independent Pathway in Pheochromocytoma Cells
- Heterotrimeric G protein y12 Subunit is Region-Specifically Expressed in Rat Brain
- Peroxynitrite Scavenging Activity of Active Constituents from Scutellaria baicalensis
- Flexible docking of novel antitumor agents into human topoisomerase l-DNA complex with FlexiDock
- Purification and Characterization of Dermatan Sulfate from Eel Skin, Anguilla japonica
- Alkaline protease of Actinomycetes CS0703：Isolation, production and characterization
- (-)-β-Narcotine：A Facile Synthesis and the Degradation with Ethyl Chloroformate
- Simultaneous quantitation of enalapril and enalaprilat in human plasma by high-throughput solid phase extraction and liquid chromatography/tandem mass spectrometry
- The Effect of Nimodipine on the Pharmacokinetics of Cyclosporine in Rabbits
- Growth inhibition and cell cycle phase-specific apoptosis induced by celecoxib in human NSCLC cells in vitro
- Incidence level ot abnormality in creatine phosphokinase by statin
- Determination of Optical Purity of a-Arylmethylpropionic acds by Normal Phase Liquid Chromatography
- Hydrogen Peroxide Activates ERK in Cultured Feline Ileal Smooth Muscle Cells
- The influence of extremely low frequency magnetic field on cardiovascular response
- Synthesis and Antifungal Activities of 2,5-Disubstituted-6-Arylamino-4,7-benzimidazolediones
- SYNTHESIS OF [1-FLUORO-2,2-BIS-(HYDROXYMETHYL) CYCLOPROPYLMETHYL] PURINESAS ANTIVIRAL AGENTS
- Antigastritic and anti-ulcerative constituent from Panax ginseng head and its pharmacological activity
- In vitro antioxidant triterpenoids from Prunus serrulata var. spontanea
- New Analytical Method of Cyclosporine A in Human Serum by High-performance Liquid Chromatography/Diode Array Detector and Its Application to Pharmacokinetics of Cyclosporine A in Human Volunteers
- Biological Activities and Constituents of the Semen of Rumex crispus
- The Differential Roles of Glutamine Synthetase in Methylmercury Neurotoxicity
- The toxicity of Aceporol 460 as a novel high loading capacity solubilizer of paclitaxel
- Role of Kupffer Cells in Alteration of Vasoregulatory Gene Expression in Hepatic Ischemia/Reperfusion
- The effects of extremely low frequency magnetic field on bicuculline, picrotoxin, NMDA-induced seizures in mice
- Histoculture drug response assay in Human colorectal cancer patients of novel Pt(Ⅳ) complex, K101 and nephrotoxicity test in ICR mice renal proximal tubular cells
- Sphingosine-1-Phosphate Decreases Melanin Synthesis via Sustained ERK Activation and Subsequent MITF Degradation
- Corticosteroids and Proximal Femur Fracture in Elderly W omen ： the KEPEC Study
- New Formulation of Vitamin A Transdermal Therapeutic System
- GENISTEIN INHIBITS NF-κB-DEPENDENT COX -2 INDUCTION IN HUMAN BREAST EPITHELIAL CELLS BY MODULATING THE ACTIVATION OF TATA-BINDING PROTEIN
- Newly Designed Six-membered Azasugar-Containing Phosphorothioate Oligonucleotide as a Potent AIDS Therapeutic Drug
- Simultaneous determination of corticosteroids in a herbal medicinal preparation by GC-MS
- Surfactant-free microspheres of poly(£-caprolactone)/poly(ethylene glycol)/poly(£-caprolactone) tribtock copolymers as a novel protein carriers
- Isolation and Structure Determination of Cytotoxic Compounds with Topoisomerse I and II Inhibitory Activity from the spikes of Prunella vulgaris var. lilacina
- Temperature Regulates Melanin Synthesis in Mel-Ab Cells
- Bioactive Fabaceous Saponins and Structure-Activity Relationship
- Development of Mechanism-based Irreversible Inhibitors of S-Adenosylhomocysteine Hydrolase as Borad-spectrum Antiviral Agents
- Three-dimensional Pharmacophore Mapping of a Series of Isoxazolylpiperazine Inhibitors Selectively acting on the Dopamine D4 Receptor
- Signaling and Proteomics in Methylmercury Exposure
- Biological Activity of Lanostane-type Triterpenes from Ganoderma lucidum
- Selectivity of the optical isomers of KR30031 on MDR reversal activity and cardiotoxicity
- The effects of estradiol and its metabolites on the regulation of CYP1A1 expression
- Immuno-modulator effect of Cefodizime in lL-6
- Proliferation of Hematopoietic Cells by Pheliinus linteus polysaccharide
- Involvement of Akt in naphthoquinone analog-induced apoptosis in HL-60 cells
- Tetrandrine induces mitochondria-dependent apoptosis in HepG2 cells
- Role of Metabolic Activation by Cytochrome P450s in Chemical-induced Immunosuppression
- IL-1β Expression of Cefodizime on Dendritic cell and Macrophage
- Alteration of Hepatic Drug Metabolizing Function after Traumatic Injury
- Flexible docking of stereoisomers of allyl substituted penam sulfones into metallo-β-lactamase with QXP
- Administration of BCG-CWS in oil-in-water emulsion inhibits tumor growth and metastasis
- Risk assessment of endocrine disruptors in cosmetics
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