Adiponectin is Associated with Impaired Fasting Glucose in the Non-Diabetic Population

• 발행기관: 한국역학회
• 저자명: Sang Yeun Kim Sun Ju Lee Hyoun Kyoung Park Ji Eun Yun Myoung sook Lee Ji dong Sung Sun Ha Jee
• 간행물 정보: 『Epidemiology and Health』33, 1~6쪽, 전체 5쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2011.01.30

영문 초록

OBJECTIVES: Adiponectin is strongly associated with diabetes in the Western population. However, whether adiponectin is independently associated with impaired fasting glucose (IFG) in the non-obese population is un-known. METHODS: The serum adiponectin, insulin resistance (IR), and waist circumference (WC) of 27,549 healthy Koreans were measured. Individuals were then classified into tertile groups by gender. IFG was defined as a fasting serum glucose of 100-125 mg/dL without diabetes. IR was calculated using the homeostasis model as-sessment of insulin resistance (HOMA-IR). The association of adiponectin and IFG was determined using lo-gistic regression analysis. RESULTS: WC and adiponectin were associated with IFG in both men and women. However, the association of WC with IFG was attenuated in both men and women after adjustment for the HOMA-IR. Adiponectin was still associated with IFG after adjustment for and stratification by HOMA-IR in men and women. Strong com-bined associations of IR and adiponectin with IFG were observed in men and women. Multivariate adjusted odds ratios (ORs) (95% confidence interval [CI]) among those in the highest tertile of IR and the lowest tertile of adiponectin were 9.8 (7.96 to 12.07) for men and 24.1 (13.86 to 41.94) for women. CONCLUSION: These results suggest that adiponectin is strongly associated with IFG, and point to adiponec-tin as an additional diagnostic biomarker of IFG in the non-diabetic population.

목차

Abstract

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

Adiponectin Diabetes Impaired fasting glucose Insulin resistance