학술논문
ADIPOQ Gene Variants Associated with Susceptibility to Obesity and Low Serum Adiponectin Levels in Healthy Koreans
이용수 2
- 영문명
- 발행기관
- 한국역학회
- 저자명
- Ji Wan Park Jung yong Park Sun Ha Jee
- 간행물 정보
- 『Epidemiology and Health』33, 1~7쪽, 전체 6쪽
- 주제분류
- 의약학 > 면역학
- 파일형태
- 발행일자
- 2011.01.30
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국문 초록
영문 초록
OBJECTIVES: This study aimed to measure the association between the adiponectin, C1Q and collagen domain-containing (ADIPOQ) gene variants and obesity in Koreans.
METHODS: Three single nucleotide polymorphisms located in the ADIPOQ gene were genotyped in a popu-lation-based cross-sectional study of 986 healthy Koreans. Three different case-control groups (i.e. G1, G2, and G3) were defined according to body mass index (BMI) and serum adiponectin levels. Allelic and genotypic as-sociations of this gene with obesity were measured using multivariate logistic regression analyses in each group.
RESULTS: The G allele of -11377C>G, a polymorphism located in the promoter region of the ADIPOQ gene (odds ratio (OR), 1.48; 95% confidence interval, 1.13-1.94) and most haplotypes including this allele signifi-cantly increased the risk for obesity. However, the OR decreased from 3.98 (G1 group) to 2.90 (G2 group) and 2.30 (G3 group) when a less strict definition of obesity was used. Most haplotypes, including this allele, signifi-cantly increased the risk of obesity. The statistical evidence from the GG genotype of -11377C>G (OR, 3.98) and the GT/GT diplotype composed of -11377G>C and +45T>G (OR, 5.20) confirmed the contribution of the G allele toward a predisposition for obesity.
CONCLUSION: These results suggest the contribution of the ADIPOQ gene toward susceptibility to obesity in healthy Koreans. The high-risk genotypes and haplotypes identified here may provide more information for identifying individuals who are at risk of obesity.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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- ADIPOQ Gene Variants Associated with Susceptibility to Obesity and Low Serum Adiponectin Levels in Healthy Koreans
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- Comments on Jo and Colleagues’ Paper (2010) “Association of Subway Driver’s Depressive Symptoms and Experience of Work-Related Problems”
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