당뇨망막병증의 전방수내 사이토카인 분석

• 영문명: Analysis of Aqueous Humor Cytokines in Diabetic Retinopathy
• 발행기관: 대한안과학회
• 저자명: 송영진 정종현 김도균,Young Jin Song, MD, Jong Hyun Jung, MD, Do Gyun Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number12, 1821~1827쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.12.15

영문 초록

Purpose: To investigate the relationship between the concentration of aqueous humor cytokines and the severity of diabetic retinopathy. Methods: Thirty-six subjects were included in the control, non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR) groups, each group has 12 patients. Aqueous levels of cytokines (interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), monocyte chemoattractant protein (MCP)-1, interferon (IFN)-γ, tumor necrosis factor (TNF)-α) were investigated according to the severity of diabetic retinopathy. Results: When the control group was compared with the PDR and NPDR groups, aqueous levels of IL-6 were significantly higher in PDR patients than in those of both the control and NPDR groups (p = 0.016 and p = 0.003, respectively). The aqueous levels of VEGF were significantly higher in the eyes of PDR patients than in those of the control group (p = 0.003). There were no statistically significant differences between the 3 groups with regard to other cytokines. Conclusions: Aqueous levels of IL-6 and VEGF were higher in the eyes of PDR patients than in those of healthy controls. J Korean Ophthalmol Soc 2014;55(12):1821-1827

키워드

Aqueous humor, Cytokine, Diabetic retinopathy