경도의 안구건조증 환자에서 굴절교정수술 전후 0.05% 사이클로스포린 사용의 효과

• 영문명: Efficacy of Topical Cyclosporine in Mild Dry Eye Patients Having Refractive Surgery
• 발행기관: 대한안과학회
• 저자명: 강건욱 김홍균,Kun Wook Kang, MD, Hong Kyun Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number12, 1752~1757쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.12.15

영문 초록

Purpose: To evaluate the efficacy of pre- and post-operative use of topical 0.05% cyclosporine A (CsA) in mild dry eye patients having refractive surgery. Methods: This randomized prospective study included 40 patients with mild dry eye syndrome who were scheduled for laser in situ keratomileusis (LASIK). All patients were divided into 2 groups. Patients in the CsA group used both 0.1% sodium hyaluronate (HA) and 0.05% CsA from 2 weeks before to 8 weeks after the surgery, while patients in the control group used 0.1% HA only. Ocular surface disease index (OSDI), tear film break-up time (TF-BUT), Oxford Stain Score (OSS), and tear osmolarity were evaluated before surgery and 1, 4, and 8 weeks after surgery. Results: TF-BUT was significantly longer in the CsA group at 1 and 4 weeks post-operatively (p = 0.024, p = 0.036) compared to the control group. Tear osmolarity was significantly lower in the CsA group at 1 week post-operatively (p = 0.004) compared to the control group. Conclusions: The pre- and post-operative use of topical 0.05% CsA is effective in alleviating dry eye symptom after LASIK in patients with dry eye syndrome. J Korean Ophthalmol Soc 2014;55(12):1752-1757

키워드

Cyclosporine, Dry eye syndrome, LASIK, Refractive surgery