인공눈물 점안제 종류에 따른 의안 표면 습윤능 비교

• 영문명: Comparison of Wettability for Ocular Prosthesis Depending on Different Kinds of Artificial Tear Eye Drops
• 발행기관: 대한안과학회
• 저자명: 장세란 윤일석 임헌섭 국경훈,Se Ran Jang, MD, Il Suk Yun, MD, Hun Sub Lim, MD, Koung Hoon Kook, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number12, 1745~1751쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.12.15

영문 초록

Purpose: In this study we compared the surface wettability of ocular prosthesis and depositions depending on different types of artificial tear eye drops. Methods: The artificial tear eye drops contain sodium hyaluronate (HA) 0.1%, 0.18%, 0.3%, carboxylmethylcellulose sodium (CMC), hydroxymethylcelluose + dextran (HMC), propylene glycol + polyethylene glycol (PG), polysorbate 80 (PS) povidone (Pov) were evaluated. Flat rectangular parallelepiped blocks consisting of polymethylmethacrylate (PMMA) or silicone materials were made. One artificial tear eye drop was applied on the surface of two different blocks of artificial eyes using a 23-gauge needle. Then, the static method contact angle was measured by using a contact angle goniometer. To measure the deposits, a petri dish was covered with 3 mL of artificial tear eye drops and dried for 48 hours at room temperature. Then, the light transmittance at the center of the petri dish was measured to investigate the amount of the residue. Results: The contact angles of HA 0.1%, 0.18%, 0.3%, CMC, HMC, PG, PS and Pov on PMMA were 78.69°, 84.29°, 75.46°, 80.93°, 66.29°, 71.26°, 58.40° and 70.24°, respectively. The contact angles on silicone were 53.68°, 60.87°, 64.46°, 62.78°, 38.89°, 63.58°, 30.68° and 51.41°, respectively. The largest decrease in transparency was observed in the artificial tear eye drops containing HMC. Conclusions: The wettability and deposits on the surface of ocular prosthesis can vary based on the components and concentration of artificial tear eye drops. The results from this study should be considered when choosing the right artificial tear eye drops for improving dry eye symptoms in patients wearing ocular prostheses. J Korean Ophthalmol Soc 2014;55(12):1745-1751

키워드

Anophthalmos, Artificial tear eye drop, Dry eye syndrome, Ocular prosthesis, Wettability