Scedosporium apiospermum에 의한 진균각막염 1예

• 영문명: A Case of Fungal Keratitis Scedosporium apiospermum
• 발행기관: 대한안과학회
• 저자명: 이샘 이동욱 이혜수 유인천,Saem Lee, MD, Dong Wook Lee, MD, Hye Soo Lee, MD, In Cheon You, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number4, 675~679쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.04.30

영문 초록

Purpose: To report a case of fungal keratitis caused by Scedosporium apiospermum. Case summary: A 70-year-old man visited our clinic with complaints of redness and decreased visual acuity in his right eye caused by a soil gotten into an eye while gardening 10 days ago. The patient had previously been treated in a local clinic but did not show significant clinical improvement. Bacterial and fungal staining, culture, and an antibiotic sensitivity test were performed from a corneal scrape. The cultures revealed growth of Scedosporium apiospermum. The patient was treated with topical moxifloxacin antibiotics, fluconazole, amphotericin B antifungal agents. However, the lesion was not improved, so antifungal therapy was switched to topical voriconazole. After two months of treatment, the infection was resolved with mild scarring. Conclusions: Although it is a rare pathogen, Scedosporium apiospermum should be considered as a potential pathogen in patients presenting with corneal ulceration due to trauma from an object contaminated by soil, polluted water, or spoiled plant contact. And we suggest that topical application of voriconazole may be a good alternative treatment for patient with fungal keratitis in which no improvement despite a conventional antifungal agent, fluconazole.

키워드

Corneal ulcer, Fungal keratitis, Scedosporium apiospermum, Voriconazole