근시성 맥락막 신생혈관의 치료 후 시력 예후와 관련된 예측인자

• 영문명: Predictive Factors for Visual Outcome after Treatment for Myopic Choroidal Neovascularization
• 발행기관: 대한안과학회
• 저자명: 오하나 이주은 김현웅 윤일한,Ha Na Oh, MD, Joo Eun Lee, MD, PhD, Hyun Woong Kim, MD, PhD, Il Han Yun, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number4, 610~617쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.04.30

영문 초록

Purpose: To determine predictive factors associated with visual outcome after treatment for myopic choroidal neovascularization (mCNV). Methods: Medical records of the patients who underwent photodynamic therapy (PDT), intravitreal anti-vascular endothelial growth factor (Anti-VEGF) injection, or combination therapy of PDT and Anti-VEGF for myopic CNV, and followed up for more than a year, were reviewed retrospectively. Multiple linear regression analyses were performed to evaluate the predictive factors significantly associated with the visual outcome at 1 year after the treatment. Results: Mean best-corrected visual acuity (BCVA) of 45 eyes of 45 patients showed statistically significant improvement 1 year after the treatment with a mean of 3.5 line improvement (p < 0.01, Wilcoxon signed rank test). Age, 1-month BCVA after treatment and treatment type appeared to be associated with the 1-year visual outcome after treatment for mCNV (p = 0.033, p < 0.001, and p = 0.044, respectively, multivariate linear regression analysis). Conclusions: Younger age (less than 40 years), better 1-month BCVA after treatment, intravitreal Anti-VEGF monotherapy were associated with improved visual outcome after treatment for mCNV. In particular, 1-month BCVA after treatment is a useful indicator to predict therapeutic response after treatment for mCNV.

키워드

Anti-VEGF, Bevacizumab, Myopic CNV, PDT, Ranibizumab